• Bleomycin sulfate, USP packaged and labeled.

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SKU: B005

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Description

Bleomycin sulfate is a water soluble anticancer chemotherapeutic agent commonly used to treat Hodgkin’s lymphoma. Bleomycin comprises a mixture of two components: bleomycin A2 and bleomycin B2. The approximate composition of A2:B2 is 2:1; however, the ratio can vary greatly depending on the lot tested.

TOKU-E offers three forms of bleomycin: bleomycin sulfate (B005), bleomycin A2 sulfate, EvoPure® (B019), and bleomycin B2 sulfate, EvoPure® (B020). EvoPure® products are individual molecular fractions, most >99% pure.

    CAS Number

    9041-93-4

    Mechanism of Action

    Bleomycin acts as an anticancer agent by causing single stranded breaks in DNA. The exact mechanism is not well defined however; it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which create single stranded breaks in deoxyribose sugar.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

Applications

    Cancer Applications

    Chemotherapeutic agent for the treatment of Hodgkin's lymphoma.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Streptomyces verticillus

    pH

    4.5 - 6.0

    Loss on Drying

    ≤6.0%

    Heavy Metals

    Copper: ≤0.1%

References

    References

    Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.

    "Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.

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