• Bleomycin sulfate, USP packaged and labeled.

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SKU: B005

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Description

Bleomycin sulfate is a chemotherapeutic agent commonly used to treat Hodgkin’s lymphoma. Bleomycin is a mixture of Bleomycin A2 and Bleomycin B2. The approximate composition of A2:B2 is 2:1. The compound is water soluble.

TOKU-E offers 5 forms of Bleomycin:

    CAS Number

    9041-93-4

    Mechanism of Action

    The exact mechanism of action Bleomycin sulfate is not well defined; however, it is thought to chelate metallic ions which decreases enzyme activity and stability. This effect is believed to cause the enzymes to react with oxygen, producing free radicals which create single stranded breaks in deoxyribose sugar.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

Applications

    Cancer Applications

    Chemotherapeutic agent for the treatment of Hodgkin's lymphoma.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Streptomyces verticillus

    pH

    4.5 - 6.0

    Loss on Drying

    ≤6.0%

    Heavy Metals

    Copper: ≤0.1%

References

    References

    Aszalos A, Crawford J, Vollmer P, Kantor N and Alexander T (1981)  High-performance liquid chromatographic determination of components of bleomycin preparations. J. Pharm. Sci 70(8):878-880  PMID

    6171636Burger RM, Paisach J, and Horwitz SB (1981) Mechanism of bleomycin action: In vitro studies. Life Sci. 28(7):715-727 PMID 6164898

    Dorr, RT (1991) Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics. Semin. Oncol. 19(2): 3-8. PMID 1384141

    Fujiwara Y and Kondo T (1973) Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo. Biochem. Pharmacol 22(3):323-333. PMID 4119868

    Kross et al. (1982) Structural basis for the deoxyribonucleic acid affinity of bleomycins. Biochem. 21: 3711-3721 PMID 6180763

    Kross et al (1982) Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Biochem. 21:4310 PMID 6181807

    Takita T et al (1972) Chemistry of bleomycin. IX. The structures of bleomycin and phleomycin. J. Antibiot. (Tokyo) 25:755-757 PMID 4119701

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