• Bleomycin packaged and labeled in glass vial.

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SKU: B053

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Description
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors.

Bleomycin is soluble in water and methanol, with moderate ethanol solubility.

    CAS Number

    9041-93-4

    Molecular Formula

    C55H84N17O21S3 (for A2)

    Molecular Weight

    1415.6 (for A2)

    Mechanism of Action

    Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Off-white solid

References

    References

    Chemistry of bleomycin. IX. The structures of belomycin and phleomycin. Takita T. et al. , J. Antibiot. 1972, 25, 755. 

    Structural basis for the deoxyribonucleic acid affinity of bleomycins. Kross J. et al. , Biochemistry 1982, 21, 3711. 

    Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Kross et al. , Biochemistry 1982, 21, 4310.

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