• Bleomycin packaged and labeled in glass vial.

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SKU: B053

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Description

Bleomycin is a complex of 11 glycopeptide antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components are Bleomycin A2 and Bleomycin B2, which typically represent >90% of the total weight. Bleomycins have antitumor properties.

TOKU-E offers five forms of Bleomycin:

Bleomycin is soluble in water and methanol, and moderately soluble in ethanol.

    CAS Number

    11056-06-7

    Molecular Formula

    C55H84N17O21S3 (for A2)

    Molecular Weight

    1415.6 (for A2)

    Mechanism of Action

    Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, Bleomycins form a pseudo-enzyme that induces DNA cleavage.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Off-white solid

References

    References

    Burger RM, Paisach J, and Horwitz SB (1981) Mechanism of bleomycin action: In vitro studies. Life Sci. 28(7):715-727 PMID 6164898

    Dorr, RT (1991) Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics. Semin. Oncol. 19(2): 3-8. PMID 1384141

    Fujiwara Y and Kondo T (1973) Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo. Biochem. Pharmacol 22(3):323-333. PMID 4119868

    Kross et al. (1982) Structural basis for the deoxyribonucleic acid affinity of bleomycins. Biochem. 21: 3711-3721 PMID 6180763

    Kross et al (1982) Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Biochem. 21:4310 PMID 6181807

    Takita T et al (1972) Chemistry of bleomycin. IX. The structures of bleomycin and phleomycin. J. Antibiot. (Tokyo) 25:755-757 PMID 4119701

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