• Bleomycin A2 sulfate, EvoPure packaged and labeled.

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SKU: B019

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Description

Bleomycin A2 Sulfate, EvoPure is a glycopeptide antibiotic used as a chemotherapeutic agent in the treatment of Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2)  and differs only by a terminal amine group. 

TOKU-E offers three four of Bleomycin sulfate: 

    CAS Number

    11116-31-7 (Bleomycin A2 base)

    Molecular Formula

    C55H84N17O21S3 · xH2SO4 (lot specific)

    Molecular Weight

    1415.55 (Free base)

    Mechanism of Action

    The exact mechanism of action is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

Applications

    Cancer Applications

    Common treatment for Hodgkin's lymphoma.

    Plant Biology Applications

    Bleomycin has been used in gene selection of tobacco, as only plants containing the Ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Streptomyces verticillus

    pH

    4.5-6.0

    Loss on Drying

    ≤6.0%

Technical Data

HPLC Chromatogram Showing Ultra High, Single Fraction Purity of Bleomycin A2 Sulfate, EvoPure®

Bleomycin A2 sulfate, EvoPure

References

    References

    Kole, C., Michler C.H., Abbott A.G. and Hall C.T. 2010. Transgenic Crop Plants: Volume 1: Principles and Development. Springer

    Miki B., McHugh S., 2003 Selectable marker genes in transgenic plants: applications, alternatives and biosafety. Journal of Biotechnology 107 (2004) 193–232.

    Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.

    "Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.

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