• Bleomycin A5 hydrochloride

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SKU: B004

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Description
Bleomycin A5 is in the same drug family as bleomycin complex. The bleomycins were originally isolated for their broad spectrum antibacterial activity, but were eventually found to be outstanding anticancer drugs. Bleomycin A5 is used in particular to treat haemangioma.

TOKU-E also offers three forms of the related product, bleomycin complex, including: bleomycin sulfate (B005), and its components bleomycin A2 sulfate, Evopure® (B019) , and bleomycin B2 sulfate, Evopure® (B020).

    CAS Number

    55658-47-4

    Molecular Formula

    C57H89N19O21S• HCl

    Molecular Weight

    1477.02

    Mechanism of Action

    Bleomycin's anticancer activities include the increase of caspase-3 and p53, and the inhibition of telomerase activity leading to apoptosis.

Applications

    Microbiology Applications

    Bleomycin A5 hydrochloride is often used to select for cells that have been transformed with a plasmid containing the Sh ble gene which confers resistance to bleomycin and bleomycin A5.

References

    References

    Huang, Y.-D., Li, P., Tong, X., He, Y., Zhuo, Y., Xia, S.-W., & Luo, X.-H. (2015). Effects of bleomycin A5 on caspase-3, P53, bcl-2 expression and telomerase activity in vascular endothelial cells. Indian Journal of Pharmacology, 47(1), 55. doi:10.4103/0253-7613.150337

    Luo, Q., & Zhao, F. (2011). The effects of Bleomycin A5 on infantile maxillofacial haemangioma. Head & Face Medicine, 7(1), . doi:10.1186/1746-160x-7-11

    Mulsant, P., Gatignol, A., Dalens, M., & Tiraby, G. (1988). Phleomycin resistance as a dominant selectable marker in CHO cells. Somatic Cell and Molecular Genetics, 14(3), 243–252. doi:10.1007/bf01534585

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