• Bleomycin A5 hydrochloride

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SKU: B004

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Description

Bleomycin A5 hydrochloride is part of the Bleomycin complex.  The Bleomycins were originally isolated for their broad spectrum antibacterial activity, but were eventually found to be useful anticancer drugs. Bleomycin A5 is used to treat haemangioma.

TOKU-E also offers five forms of Bleomycin:

    CAS Number

    55658-47-4

    Molecular Formula

    C57H89N19O21S• HCl

    Molecular Weight

    1477.02

    Mechanism of Action

    Bleomycin causes an increase of caspase-3 and p53, and inhibits telomerase activity leading to apoptosis.

Applications

    Cancer Applications

    Infantile haemangioma can be effectively treated with Bleomycin A5.

    Microbiology Applications

    Bleomycin A5 hydrochloride is used in gene selection using the Sh ble gene which confers resistance to Bleomycin and Bleomycin A5.

References

    References

    Burger RM, Paisach J, and Horwitz SB (1981)  Mechanism of bleomycin action: In vitro studies. Life Sci. 28(7):715-727  PMID 6164898

    Dorr, RT (1991)  Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics. Semin. Oncol. 19(2): 3-8. PMID 1384141

    Fujiwara Y and Kondo T (1973)  Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo.  Biochem. Pharmacol 22(3):323-333.  PMID 4119868

    Huang, YD et al (2015). Effects of bleomycin A5 on caspase-3, P53, bcl-2 expression and telomerase activity in vascular endothelial cells. Ind. J. Pharmacol 47(1):55 

    Kross et al. (1982)  Structural basis for the deoxyribonucleic acid affinity of bleomycins. Biochem. 21: 3711-3721  PMID 6180763

    Kross et al (1982)  Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Biochem. 21:4310  PMID 6181807

    Luo, Q and Zhao F (2011). The effects of Bleomycin A5 on infantile maxillofacial haemangioma. Head Face Med. 7(1), doi:10.1186/1746-160x-7-11  PMID 21736714

    Mulsant P, Gatignol A, Dalens M and Tiraby, G (1988). Phleomycin resistance as a dominant selectable marker in CHO cells. Som. Cell and Mol.  Gen. 14(3):243–252  PMID: 2453083

    Takita T et al  (1972)  Chemistry of bleomycin. IX. The structures of bleomycin and phleomycin. J. Antibiot. (Tokyo) 25:755-757 PMID 4119701

     

     

     

     

     

     

     

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