Piliformic Acid is produced by fungi including Xylaria sp. Piliformic acid has mild inhibitory activity against Propionobacterium acnes, inhibiting the P. acnes-induced pro-inflammatory cytokines production in THP-1 cells. Piliformic acid is active against the plant fungal pathogen Colletotrichum gloeosporioides with MIC 2.92 μmol/mL and has antileishmanial activity.
