SKU: Z006  / 
    CAS Number: 142561-96-4

    Zaragozic acid A

    $142.23 - $497.81
    Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. Zaragozic acid A is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.

    Zaragozic acid A is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionZaragozic acid A is an inhibitor of squalene synthase, an enzyme involved in sterol biosynthesis.
    ReferencesThe zaragozic acids. A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Bergstrom J.D. et al. Proc. Nat. Acad. Sci. 1993, 90, 80.

    Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes. Bills G.F. Mycol. Res. 1994, 98, 733-739.