Cyclosporin D, EvoPure® is a hydroxylated metabolite of Cyclosporin A. Cyclosporin D and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin A. Cyclosporin D has been found to reverse daunorubicin resistance in some resistant leukemia cells by possibly inhibiting the efflux functions of P-glycoprotein.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
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