SKU: C044  / 
    CAS Number: 59787-61-0

    Cyclosporin C, EvoPure®


    Cyclosporin C, EvoPure® is a hydroxylated metabolite of Cyclosporin A.  Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A.  Cyclosporin C also has antimycotic properties.

    EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.

    For more Cyclosporin products, click here.

    Mechanism of Action Cyclosporin C and other metabolites of Cyclosporin A have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A.  Cyclosporin A immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, Cyclosporin A associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A:cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation.
    Cancer Applications Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.
    Molecular Formula C62H111N11O13

    Copeland KR, Yatscoff RW and McKenna RM (1990)  Immunosuppressive activity of Cyclosporine metabolites compared and characterized by mass spectrometry and nuclear magnetic resonance. Clin. Chem. 36(2):225-229 PMID 2137384 

    Ho S et al (1996)  The mechanism of action of Cyclosporin A and FK506. Clin. Immunol. and Immunother.  80(3 Pt 2):S40-5  PMID 8811062

    Laupacis A, Keown PA, Ulan RA, McKenzie N and Stiller CR (1982) Cyclosporin A: A powerful immunosuppressant.  Can. Med. Assoc.  126(9): 1041-1046  PMID 7074504

    Matsuda S and Koyasu S (2000)  Mechanisms of action of Cyclosporine.  Immunopharmacol. 47(2-3):119-125  PMID 10878286

      Wang CP et al (1989)  Isolation of 10 Cyclosporine metabolites from human bile. Drug Metab. and Disposition 17 (3):292-296  PMID 2568911