Cyclosporin C is a hydroxylated metabolite of cyclosporin A (CsA). Cyclosporin C has been found to have similar immunosuppressant activity, but lower nephrotoxicity than cyclosporin A (CsA). Cyclosporin C has also been found to have antimycotic properties.
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|Mechanism of Action|
Cyclosporin C (and other cyclosporin A (CsA) metabolites) have lower immunosuppressant activity but most likely operate under the same mechanism as cyclosporin A (CsA) described below.Cyclosporin A (CsA) immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, cyclosporin A (CsA) associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A (CsA) : cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation.
|Cancer Applications||Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.|
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