SKU: B038  / 
    CAS Number: 88899-55-2

    Bafilomycin A1

    ₹24,966.85 - ₹87,384.52

    Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

    Bafilomycin A1 is soluble in ethanol, methanol, DMF and DMSO. NOTE: forms methyl ketal on long term storage in methanol.

    Mechanism of Action Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.
    References Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Bowman E.J. et al. Proc Natl Acad Sci USA. 1988, 85, 7972. 

    Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. Yoshimori T. et al. J Biol Chem. 1991, 266, 17707. 

    Vacuolar ATPase as a drug discovery target. Niikura K. Drug News Perspect. 2006, 19, 139.