SKU: T075  / 
    CAS Number: 70497-14-2

    Teleocidin A1

    ฿14,783.40 - ฿51,627.30
    Teleocidin A is a potent nematocide and acaricide produced by Streptoverticillium strains, first reported in 1960. Teleocidin A is a potent activator of protein kinase C, and also a tumor promoting agent and inducer of colony-stimulating factors. More recently, teleocidin A1 has been shown to regulate the expression of several genes. To date, the lack of availability of teleocidin has meant the truncated teleocidin-like (-)indolactam has been used to mimic teleocidin cellular responses.

    Teleocidin A is soluble in ethanol, methanol, DMF and DMSO.
    Molecular FormulaC27H39N3O2
    ReferencesA new toxic substance, teleocidin, produced by Streptomyces. Part I. Production, isolation and chemical studies. Takashima M. & Sakai H. Bull. Agr. Chem. Soc. Japan 1960, 24, 647.

    Screening method for colony-stimulating factor inducers using a human bone marrow stromal cell line, KM-102. Kohama T. et al. J. Antibiot. 1993, 46, 1494.

    Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays. Kikuchi H. J. Nat. Prod. 2010, 73, 452.