BioActive Small Molecules

Midostaurin

Midostaurin is an organic protein kinase inhibitor for tyrosine kinase, protein kinase C, and VEGF. It is an organic heterooctacyclic compound that is the N-benzoyl derivative of stauroporine, an alkaloid from Streptomyces staurosporeus. It has been...

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Lefamulin Acetate

Lefamulin Acetate is a pleuromutilin antibiotic, a group originally isolated from basidiomycetes and developed in the 1950s. Lefamulin was introduced by Nabriva Therapeutics and approved for use in US in 2019. In fact, it was the first pleuromutilin to...

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Fluvoxamine Maleate

Fluvoxamine Maleate is a selective neuronal serotonin reuptake inhibitor with a 100-fold affinity for the serotonin transporter over the norepinephrine transporter. It is an aralkylketone-derivative agent developed by Solvay, Belgium. It inhibits many...

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Nafamostat Mesylate

Nafamostat Mesylate is a synthetic serine protease inhibitor, inhibiting a number of Lys/Arg-specifc serine proteinases. It is a tryptase inhibitor. It is an anticoagulant. proventing the proteolysis of fibrinogen into fibrin. The compound has...

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WIN 66306

WIN 66306 is a cyclic peptide discovered during a search for inhibitors of Substance P binding to neurokinin (NK) receptors by Sterling Winthrop Pharmaceuticals in 1994. WIN 66306, isolated from Aspergillus sp., is active at both the NK1 and NK2 receptor...

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WF 3681

WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of...

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WEB 2086

WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8 to 10-6 mol​/L strongly and...

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Securinine

Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar. Securinine inhibits [3H]GABA binding to rat brain...

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Indole-3-carboxaldehyde

Indole-3-carboxaldehyde is an endogenous metabolite of plants and is produced in humans by the metabolism of L-tryptophan in Lactobacillus and other gastrointestinal bacteria. Indole-3-carboxaldehyde is an immunomodulator, acting as an agonist of the...

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hemi-Oxanthromicin

hemi-Oxanthromicin is the monomer of (±)-oxanthromicin, first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. Unlike its co-metabolites, oxanthromicin and spiro-oxanthromicin, hemi-oxanthromicin does not inhibit...

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Fumitremorgin B

Fumitremorgin B is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Fumitremorgin B is active against a range of phytopathogenic fungi including Botrytis cinerea, Alternaria solani and alternata at 6.25 µg/mL. Fumitremorgen B has potent...

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Circumdatin A

Circumdatin A, produced by Aspergillus sp., was first reported in 1999 by Rahbaek and colleagues, University of Copenhagen, Denmark. The structure of circumdatin A was revised as a unique oxepine in 2008 using X-ray crystallography. Lack of availability...

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