Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Nalidixic Acid Sodium, CulturePure is a synthetic 1,8-naphthyridone antibiotic similar in structure and mechanism to quinolones, the commercial preparation of which was developed by Sanofi Aventis. The product is commonly used as a selective agent...
Sulfamethizole is a broad-spectrum sulfathiazole antibacterial of the Sulfonamide class, used for the bacteria causing urinary tract infections. Acting as a synthetic analog of para-aminobenzoic acid (PABA), it competitively inhibits this...
Oseltamivir Phosphate is an inhibitor of influenza viral neuraminidase. It is also an antiviral used against influenza A and B. Oseltamivir was discovered at Gilead in 1997 using shikimic acid as a starting point for synthesis. The...
Posaconazole is a synthetic, broad-spectrum, second generation triazole with antifungal activity. It has potent in vitro and in vivo trypanocidal activity. It was discovered by Schering-Plough and it is a structural analog of itraconazole. It has...
Ceftazidime Hydrochloride is a non-toxic hydrochloride salt derivative of Ceftazidime, a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis. Patented in 1979 by Glaxo Group, it came into...
Micafungin Sodium is the sodium salt of the semi-synthetic cyclic lipopeptide Micafungin. Micafungin is an antifungal compound belonging to the antifungal class known as echinocandins. It was reported in 1999 by Fujisawa (Japan). It is...
O-Methylviridicatin is a natural derivative of the alkaloid mycotoxin viridicatin produced by several species of Penicillium. The scaffold of quinolin-2(1H)-one is a useful structural motif found in many natural products. In particular,...
Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...
Tenofovir alafenamide is an antiretroviral developed by Gilead and the anti-HIV activity was reported in 1993. It is an investigational precursor to Tenovor, a nucleotide reverse transcriptase inhibitor. Tenofovir alafenamide is...
Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export. It is isolated from Streptomyces spp., and displays anti-cancer activity. Anguinomycins B, C and D are also members of the Leptomycin...
Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological...
Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains. It is a bioactive small molecule with antifungal and antibacterial activity. It is a nuclear export inhibitor,...
