Cycloheximide, CulturePure<sup>®</sup>

Cycloheximide, Ultrapure packaged and labeled.

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Cycloheximide, CulturePure^®

SKU: C071

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Description

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells and is commonly used to prevent fungal growth. Cycloheximide CulturePure^® is ≥98% pure and is free of toxic isomers that can potentially kill wanted fungi in a selection media.

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This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

CAS Number

66-81-9

Molecular Formula

C₁₅H₂₃NO₄

Molecular Weight

281.35

Mechanism of Action

Cycloheximide prevents ribosomal translocation during translation as shown in a yeast model. Effective doses are present at concentrations around 200 µM to inhibit yeast growth.

Storage Conditions

Ambient

Tariff Code

2941.90.1050

Applications

Plant Biology Applications

Cycloheximide is a frequently used lab reagent to inhibit fungal growth by targeting protein synthesis. In yeast, concentrations of 200 µM have fungicidal effects. (Schneider-Poetsch, 2010).

Specifications

Form

Powder

Appearance

White or cream-colored powder

Source

Streptomyces Griseus

Potency (on a dry basis)

≥900 u/mg (on dried basis)

Melting Point

107-120°C

Loss on Drying

≤1.0%

Technical Data

References

Doyle S.M., Diamond M. and McCabe P.F, 2009, Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures. Journal of Experimental Botany, Vol. 61, No. 2, pp. 473–482, 2010

Schneider-Poetsch T., Ju J., Eyler D.E., Dang Y., Bhat S., Merrick W.C., Green R. and Shen B., 2009, Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature chemical biology, vol 6, march 2010.