SKU: O004  / 
    CAS Number: 2058-46-0

    Oxytetracycline Hydrochloride

    $42.33 - $167.10

    Oxytetracycline was the second discovered tetracycline antibiotic.

    TOKU-E offers two forms of oxytetracycline: Oxytetracycline Dihydrate (O003)and Oxytetracycline Hydrochloride (O004). Oxytetracycline dihydrate is sparingly soluble in aqueous solution at 0.6 mg/mL. Oxytetracycline HCl is slightly soluble in aqueous solution at 6.9 mg/mL.

    Mechanism of ActionThe mechanism of oxytetracycline involves diffusing through a cell and binding to the 30s ribosomal subunit preventing peptide elongation and ultimately inhibiting protein synthesis. Resistance to oxytetracycline can be a result of inactivation by cell enzymes or pumping the antibiotic out of the cell upon entering.
    SpectrumOxytetracycline is a broad spectrum antibiotic which targets gram positive and gram negative species as well as a few Mycoplasma species
    Microbiology ApplicationsOxytetracycline is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 1.6 µg/mL – 6.3 µg/mL
    • Mycoplasma bovis 0.12 µg/mL - 4 µg/mL
    • For a complete list of oxytetracycline MIC values, click here.

    Media Supplement

    Oxytetracycline is used as a selective agent in OGYE, a selective media for yeasts and molds.

    Plant Biology ApplicationsOxytetracycline has been used to prevent fire blight in apple and pears in the Pacific Northwest of the USA. In a study by Hubbard et al., oxytetracycline was shown to be a better alternative to streptomycin to inhibit fire blight disease.
    Molecular FormulaC22H24N2O9•HCl
    SolubilityEthanol (95%) 33 mg/mL
    Ethanol (absolute): 12 mg/mL
    Water: Freely soluble
    Note: Concentrated aqueous solutions at neutral pH hydrolyze and precipitates crystals of oxytetracycline
    References

    Chopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance." Microbiology and Molecular Biology Reviews (2001): 232-60. Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.

    Hubbard A.R., 2011, Evaluation of Kasugamycin-use strategies Designed to Delay Development of Resistance in Erwinia amylovora. Master thesis of Botany and Plant Pathology, Oregon state University.

    MICBacillus cereus| ≥1|| Bacillus pumilus| 2|| Bacillus subtilis| ≥16|| Brochothrix thermosphacta| ≥124|| Burkholderia mallei| 16 - 32|| Clavibacter michiganensis subsp. michiganensis (185. 2. 1)| ≥4|| Diplococcus pneumoniae| 0.04 - 0.4|| Enterococcus faecalis| 0.78 - >100|| Enterococcus faecium| 0.39 - >100|| Enterococcus hirae| 0.39 - >100|| Enterococcus sp. (Uraguay)| ≤0.25 - 2|| Escherichia coli | 0.25 - 70|| Flavobacterium columnare| ≥15.63|| Fusobacterium necrophorum| 0.03 - 4.1|| Haemophilus influenzae| 1.6 - 6.3|| Haemophilus parasuis| 0.25 - 16|| Klebsiella pneumonia| ≥16|| Listeria monocytogenes| ≥58|| Micrococcus kristinae| 1 - 4|| Micrococcus luteus| ≥4|| Mycoplasma bovis | 0.12 - 128|| Mycoplasma gallisepticum| 0.05 - 200|| Mycoplasma hyopneumoniae| 0.03 - 4|| Mycoplasma hyosynoviae| 0.5 - >4|| Mycoplasma iowae| 0.025 - 100|| Mycoplasma meleagridis| 0.05 - 25|| Mycoplasma synoviae | 0.025 - 100|| Nocardia asteroides| 25 - 100|| Paenibacillus larvae| 0.016 - 0.031|| Pasteurella haemolytica| ≥64|| Proteus vulgaris| 16 - 64|| Pseudomonas aeruginosa | ≥8|| Pseudomonas flourescens| ≥40|| Salmonella enterica| ≥112|| Salmonella spp.| ≥2|| Shigella flexneri| ≥1|| Staphylococcus (coagulase-negative + Uruguay)| ≤0.25 - >64|| Staphylococcus aureus| ≤0.25 - 76|| Staphylococcus epidermidis| ≥4|| Streptococcus agalactiae| ≤0.25 - 2|| Streptococcus dysgalactiae | >4 - >64|| Streptococcus faecalis| ≥8|| Streptococcus iniae| ≥10|| Streptococcus pneumonia| 0.125 - 0.5|| Streptococcus uberis (Uruguay)| ≤0.25 - 64|| Treponema hyodysenteriae | 0.78 - 25|| Vibrio cholerae| ≥56|| Vibrio harveyi| ≥0.78||