Neoantimycin is a rare and unusual ring-extended member of the antimycin class. Neoantimycin is produced by a Streptomyces species unrelated to antimycin-producing strains. Literature references to neoantimycin are limited but the recent discovery of the closely related metabolite, prunustatin A, as a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes.
Neoantimycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
|Caglioti L (1969) The structure of neoantimycin. Tetrahedron. 25:2913
Umeda Y et al (2005) Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger. J.Antibiot. 58:206