SKU: L067  / 
    CAS Number: 16595-80-5

    Levamisole Hydrochloride, USP

    ₹12,874.05
    Levamisole Hydrochloride, USP

    Levamisole Hydrochloride, USP is the pure levorotatory (L) isomer of Tetramisole. This imidazothiazole is responsible for almost all of the antiparasitic activity of this product. It is a nicotinic acetylcholine receptor agonist. It is more refined than Tetramisole HCl due to the removal of the D-isomer of which is associated with toxicity. Levamisole HCl can be used in veterinary research and forensics applications. Levamisole is also an immunomodulator and can restore T-cell function. The compound can be used for in vitro cancer research.

    We also offer:

    • Tetramisole Hydrochloride (T061)
    Molecular Formula

    C11H12N2S · HCl
    Mechanism of Action

    Levamisole HCl is a nicotinic acetylcholine receptor agonist causing parasite paralysis due to sustained contraction of the isolated somatic muscles. It blocks neuromuscular transmission via non-competitive depolarization. In cultured cells, this compound inhibits enzyme activity by binding to sulfhydryl group of cysteine residues at the enzyme active site. The product also inhibits sodium carbonate-stimulated ATPase activity.
    Spectrum

    Levamisole HCl is a nematocidal agent with activity against a large number of nematodes including roundworms and hookworms. For example, it has activity against the roundworm Ascaris lumbricoides, the causal agent of ascariasis. It also has activity against the hookworm Ancylostoma, the causal agent of Ancylostomiasis.
    Eukaryotic Cell Culture Applications

    Levamisole levels in plasma samples can be measured via gas chromatography and high pressure liquid HPLC analysis.
    Levamisole can modulate the cell-mediated immune response and restore T cell function.
    Cancer Applications

    Levamisole HCl has anti-cancer activity, since it has chemotherapeutic agent in colorectal cancer research. Its activity may be due to IL-1 production and direct macrophage activation.
    In vitro, Levamisole can potentiate the proliferative effect of 5-fluorouracil in many types of tumor cell lines; but its mode of action and its molecular targets in these cells remains to be investigated. The effect of Levamisole on the proliferative response of the human multiple myeloma cell lines RPMI 8226 and U266B1 was studied in vitro. Authors found adding varying concentrations of Levamisole for 48 and 72 hours in cell culture resulted in a significant inhibition of proliferation in a dose-dependent way. Proposed mechanism of action is via induced apoptosis in myeloma cells (Ramanadham M, Nageshwari, 2010).
    References

    Aronson JK (2006) Levamisole. In: Meyler's Side Effects of Drugs: The International encyclopedia of ddverse drug reactions and interactions. Elsevier. (15th ed.); pp. 2028-2025

    Ramanadham M and Nageshwari B (2010) Anti-proliferative effect of Levamisole on human myeloma cell lines in vitro. J Immunotoxicol. 7(4):327-332 PMID 20860474