Demethylbleomycin A2 sulfate, EvoPure® (bleomycin impurity D) is a demethylated form of bleomycin A2 - a major component in standard grade bleomycin. Demethylbleomycin A2 is formed by heating bleomycin A2. Demethylbleomycin A2 comprises approximately 3.0% of standard grade bleomycin. Demethylbleomycin A2 has been found to have high antimicrobial activity against Mycobacterium smegmatis compared to bleomycin A2. Additionally, demethylbleomycin A2 has a lower toxicity profile and greater antitumor properties than bleomycin A2.
|Molecular Formula||C54H81N17O21S3 · xH2SO4|
|References||Umezawa, Hamao. "Method for Preparing 3-(methylmercaptol) Propylaminobleomycin." Google Patents. N.p., n.d. Web. 25 Mar. 2014.|