Candicidin is a fungicidal polyene antifungal agent derived from Streptomyces griseus, named for its high activity against the yeast Candida albicans.
|Mechanism of Action||Candicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death.|
|Spectrum||Candicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans.|
|References||Hammond, SM., and Kliger BN (1976) Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans." Antimicrob. Agents Chemother. 9(4): 561-568|
Waksman, SA et al. (1965) Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization 33(2): 219-226