SKU: C002  / 
    CAS Number: 1403-17-4

    Candicidin

    S/.738.19 - S/.2,583.64

    Candicidin is a fungicidal polyene antifungal agent derived from Streptomyces griseus, named for its high activity against the yeast Candida albicans.

    Mechanism of ActionCandicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death.
    SpectrumCandicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans.
    Molecular FormulaC59H84N2O18
    ReferencesHammond, SM., and Kliger BN (1976)  Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans." Antimicrob. Agents Chemother. 9(4): 561-568

    Waksman, SA et al. (1965) Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization 33(2): 219-226