Candicidin is a fungicidal polyene antifungal agent derived from Streptomyces griseus, named for its high activity against the yeast Candida albicans.
|Mechanism of Action||Candicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death.|
|Spectrum||Candicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans.|
|References||Hammond, SM and Kliger BN (1976) Mode of action of the polyene antibiotic Candicidin: Binding factors in the wall of Candida albicans. Antimicrob. Agents Chemother. 9(4):561-568 |
Waksman SA et al (1965) Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization 33(2): 219-226