SKU: A024

    Azithromycin dihydrate

    $240.71

    Azithromycin dihydrate is a broad-spectrum macrolide antibiotic (azalide subclass) derived from Erythromycin.  It is effective against many Gram-negative and Gram-positive bacteria and certain Mycoplasma species.   Azithromycin also has anti-immunomodulatory/anti-inflammatory properties.  Azithromycin dihydrate is sparingly soluble in aqueous solution (0.54 mg/mL).

    We also offer the following derivatives:

    Mechanism of ActionMacrolide antibiotics inhibit bacterial growth by binding to the 70S ribosome (specifically the 50S subunit) preventing peptide bond formation and translocation during protein synthesis. Resistance is attributed to mutations in 50S rRNA preventing binding of Azithromycin and allowing the cell to synthesize error-free proteins.
    SpectrumAzithromycin is effective against several Gram-positive and Gram-negative bacteria, and certain Mycoplasmas.
    Microbiology ApplicationsAzithromycin dihydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Chlamydia trachomatis 0.016 µg/mL-0.125 µg/mL
    • Mycobacterium avium 16 µg/mL- >256 µg/mL
    • For a complete list of azithromycin MIC values, click here.
    CAS Number117772-70-0 9 (dihydrate); 83905-01-5 (anhydrous); 121479-24-4 (monohydrate)
    Molecular FormulaC38H72N2O12•2H2O
    References

    Gladue RP, Bright GM, Isaacson RE and Newborg MF (1989) In vitro and in vivo uptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33(3):277-282 PMID 2543276

    Lovmar, M, and Tenson T (2003) The Mechanism of action of Macrolides, Lincosamides and Streptomycin B reveals the nascent peptide exit path in the ribosome. J. Mol. Microbiol. 330(5):1005-1014. PMID 10348778

    Wolf K and Malinverni R (1999) Effect of Azithromycin plus Rifampin versus that of Zithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis. Antimicrob. Agents Chemother. 43(6): 1491-3 PMID 10348778

    MICAggregatibacter actinomycetemcomitans| <2|| Bacillus circulans| ≤0.03 - >32|| Bacteroides capillosus| ≤0.03 - 0.25|| Bacteroides tectum | 0.5 - 2|| Bacteroides ureolyticus| ≤0.03 - 0.25|| Bifidobacterium breve| ≤0.03 - >32|| Bifidobacterium longum| ≤0.03 - >32|| Bilophila wadsworthia| 1 - 16|| Borrelia afzelii| 0.0004 - 0.0156|| Borrelia bissettii| 0.0039 - ?|| Borrelia burgdorferi| ≤0.0002 - 3|| Borrelia garinii| 0.0004 - 0.0156|| Borrelia valaisiana| 0.0009 - ≤0.015|| Brevibacterium spp.| ≤0.03 - >128|| Brucella melitensis| <0.125 - >256|| Campylobacter concisus| ≤0.03 - 0.5|| Campylobacter gracilis | ≤0.03 - 0.5|| Campylobacter mucosalis| ≤0.03 - 0.5|| Campylobacter rectus| ≤0.03 - 0.5|| Campylobacter showae| ≤0.03 - 0.5|| Campylobacter spp.| 0.25|| Campylobacter sputorum| ≤0.03 - 0.5|| Candida| >32|| Capnocytophaga ochracea| ≤0.03 - 0.25|| Chlamydia pneumonia| 0.015 - 0.5|| Chlamydia trachomatis| 0.016 - 0.125|| Chlamydophila pneumonia| 0.012 - 0.5|| Citrobacter koseri| 2 - >8|| Clostridium clostridioforme| 0.125 - >32|| Clostridium difficile| 1 - >32|| Clostridium innocuum| 0.125 - >32|| Clostridium ramosum| 0.125 - >32|| Collinsella aerofaciens| ≤0.03 - 0.25|| Corynebacterium afermentans| 0.03 - >128|| Corynebacterium amycolatum| 0.125 - >128|| Corynebacterium jeikeium| 0.06 - >128|| Corynebacterium minutissimum| ≤0.03 - >128|| Corynebacterium pseudodiphtheriticum| ≤0.015 - >128|| Corynebacterium spp.| 0.03 - >128|| Corynebacterium striatum| 0.03 - >128|| Corynebacterium urealyticum| ≤0.015 - >128|| Coryneform (CDC group| 0.03 - >128|| Dialister pneumosintes| ≤0.03 - 0.25|| Edwardsiella hoshinae | 2 - 16|| Edwardsiella ictaluri | 0.5 - 32|| Edwardsiella tarda| 4 - 16|| Eikenella corrodens| 0.25 - 8|| Enterobacteriaceae| 0.25 - 128|| Enterococcus| 0.06 - ≥512|| Erysipelothrix rhusiopathiae| 0.03|| Escherichia coli| ≤0.0156 - 512|| Eubacterium lentum| ≤0.03 - 0.25|| Eubacterium saburreum| ≤0.03 - 0.125|| Eubacterium spp.| ≤0.03 - 0.25|| Eubacterium timidum| ≤0.03 - 0.25|| Eubacterium yurii| ≤0.03 - 0.25|| Finegoldia magna| ≤0.03 - >32|| Fusobacterium gonidiaformans | 0.06 - 32|| Fusobacterium mortiferum| 1 - >32|| Fusobacterium naviforme| ≤0.03 - 32|| Fusobacterium necrogenes | 1 - >32|| Fusobacterium necrophorum| ≤0.03 - 32|| Fusobacterium nucleatum| ≤0.03 - >64|| Fusobacterium russii | 0.03 - 32|| Fusobacterium ulcerans | 1 - >32|| Fusobacterium varium| 2 - >32|| Haemophilus influenzae| 0.001 - >256|| Helicobacter pylori| 0.06 - >128|| Klebsiella oxytoca| 8 - >8|| Lactobacillus catenaforme| ≤0.03 - >32|| Lactobacillus delbrueckii | ≤0.03 - >32|| Lactobacillus oris| ≤0.03 - >32|| Lactobacillus plantarum| ≤0.03 - >32|| Lactobacillus spp. | ≤0.03 - >32|| Legionella pneumophila| 0.008 - 2|| Legionella spp.| 0.12 - 2|| Leptotrichia buccalis| ≤0.03 - 1|| Listeria monocytogenes| 0.125 - 2|| Micromonas micros| ≤0.03 - 0.5|| Moraxella catarrhalis| ≤0.008 - ≥64|| Morganella morganii| 8 - >8|| Mycobacterium abscessus| 0.5 - >64|| Mycobacterium avium| 4 - >256|| Mycobacterium chelonae| 0.25 - 4|| Mycobacterium fortuitum| 1 - >64|| Mycobacterium malmoense| 16|| Mycobacterium mucogenicum| 0.12 - 1|| Mycobacterium peregrinum| 0.5 - 4|| Mycobacterium simiae| 4|| Mycobacterium xenopi| 1|| Mycoplasma fermentans| 2 - 8|| Mycoplasma genitalium| ≤0.015 - 0.03|| Mycoplasma hominis| 32 - >64|| Mycoplasma hyopneumoniae| 0.0625 - >64|| Mycoplasma penetrans| 0.12 - 0.5|| Mycoplasma pneumonia| 0.00024 - 3.2|| Neisseria cinerea| 0.5 - 4|| Neisseria lactamica| 1 - 2|| Neisseria meningitidis| ≤0.03 - 2|| Neisseria mucosa| 0.06 - 8|| Neisseria perflava/sicca| 0.25 - 4|| Neisseria polysaccharea| 0.03 - 0.25|| Oerskovia spp.| 0.03 - >128|| Olsenella uli | ≤0.03 - >32|| Pasteurella multocida| 0.05|| Peptostreptococcus anaerobius| ≤0.03 - >32|| Peptostreptococcus asaccharolyticus| 0.5 - >32|| Peptostreptococcus magnus| 2 - >32|| Peptostreptococcus micros| 0.5 - 1|| Peptostreptococcus prevotii| 0.06 - >32|| Peptostreptococcus spp.| 2 - 4|| Porphyromonas asaccharolytica| 0.125 - >32|| Porphyromonas cangingivalis | 0.125 - 1|| Porphyromonas canoris | 0.125 - 0.5|| Porphyromonas cansulci | 0.125 - 1|| Porphyromonas circumdentaria | 0.125 - 1|| Porphyromonas endodontalis| ≤0.03 - 0.25|| Porphyromonas gingivalis| ≤0.03 - 8|| Porphyromonas levii | 0.125 - 1|| Porphyromonas macacae | 0.125 - 1|| Prevotella bivia| 0.25 - >32|| Prevotella buccae| 0.06 - >32|| Prevotella buccalis| 0.03 - >32|| Prevotella corporis| ≤0.03 - 8|| Prevotella dentalis| ≤0.03 - >32|| Prevotella denticola| 0.06 - >32|| Prevotella disiens| ≤0.03 - >32|| Prevotella heparinolytica | 0.5 - 1|| Prevotella intermedia| ≤0.03 - >32|| Prevotella loescheii| ≤0.03 - 32|| Prevotella melaninogenica| ≤0.03 - >32|| Prevotella nigrescens| ≤0.03 - >32|| Prevotella oralis| ≤0.03 - >32|| Prevotella oris| ≤0.03 - >32|| Prevotella pallens| ≤0.03 - >32|| Prevotella spp.| ≤0.03 - >32|| Prevotella tannerae| ≤0.03 - 8|| Prevotella zooglioformans| ≤0.03 - >32|| Propionibacterium avidum| ≤0.03 - >32|| Pseudomonas aeruginosa | 125 - 2000|| Rhodococcus equi| 0.03 - >4|| Salmonella spp.| 1|| Selenomonas flueggei | ≤0.03 - 0.25|| Selenomonas infelix| ≤0.03 - 0.25|| Selenomonas spp.| ≤0.03 - 0.25|| Shigella spp.| 0.5|| Staphylococci | 0.06 - ≥64|| Staphylococcus aureus| 0.12 - >128|| Staphylococcus epidermidis| <0.12 - >128|| Staphylococcus haemolyticus| 0.25 - >8|| Staphylococcus hominis| 0.12 - >8|| Staphylococcus lugdunensis| 0.25 - >8|| Staphylococcus pneumonia| >16|| Staphylococcus saprophyticus| 0.12 - >64|| Staphylococcus spp. | 0.5 - >32|| Staphylococcus warneri| 0.12 - >8|| Streptococci| ≤0.008 - >256|| Streptococcus agalactiae| 0.008 - >64|| Streptococcus anginosus| 0.008 - >8|| Streptococcus bovis| 0.008 - >8|| Streptococcus constellatus| 0.008 - >8|| Streptococcus intermedius| 0.008 - >8|| Streptococcus mitis| 0.008 - >8|| Streptococcus oralis| 0.008 - >8|| Streptococcus pneumonia| 0.004 - >512|| Streptococcus pyogenes| 0.001 - >256|| Streptococcus salivarius| 0.008 - >8|| Streptococcus sanguinis| 0.008 - >8|| Streptococcus spp.| ≤0.06 - >8|| Turicella otitidis| 0.03 - >128|| Ureaplasma spp.| 0.063 - 4|| Ureaplasma urealyticum | 0.06 - 0.5|| Veillonella spp.| ≤0.03 - >32||