• Azithromycin impurity H, EvoPure packaged and labeled.

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SKU: A084

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Azithromycin impurity H, EvoPure® (3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethylazithromycin) is one of several impurities found in Azithromycin and can be used as a reference standard for impurity profiing.

TOKU-E carries the following Azithromycin derivatives:

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    Azithromycin inhibits bacterial growth by binding to the 70S ribosome (specifically the 50S subunit) preventing peptide bond formation and translocation during protein synthesis. Resistance is attributed to mutations in 50S rRNA preventing binding of Azithromycin and allowing the cell to synthesize error-free proteins.

    Storage Conditions


    Tariff Code




    Azithromycin impurity H is primarily used as a reference standard. Reference standards are well characterized compounds that can be used to help identify and/or quantify impurities in pharmaceutical compounds and antimicrobials.

Technical Data

HPLC Chromatogram for Azithromycin Impurity H, EvoPure® 



    Gladue RP, Bright GM, Isaacson RE, Newborg MF (1989) In vitro and in vivo uptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33(3):277-282 PMID 2543276

    Lovmar, M and Tenson T (2003) The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330 (5):1005-1014. PMID 12860123

    Wolf K and Malinverni R (1999) Effect of Azithromycin plus Rifampin versus that of Azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis. Antimicrob. Agents Chemother. 43(6):1491-1493. PMID 10348778

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