• Azithromycin impurity E, EvoPure packaged and labeled.

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SKU: A074

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Description

Azithromycin impurity E, EvoPure® (Aminoazithromycin) is one of several impurities found in Azithromycin and can be used as a reference standard for impurity profiling.

TOKU-E carries the following Azithromycin derivatives:

    CAS Number

    612069-27-9

    Molecular Formula

    C36H68N2O12

    Molecular Weight

    720.942

    Mechanism of Action

    Azithromycin inhibits bacterial growth by binding to the 70S ribosome (specifically the 50S subunit) preventing peptide bond formation and translocation during protein synthesis. Resistance is attributed to mutations in 50S rRNA preventing binding of Azithromycin and allowing the cell to synthesize error-free proteins.

    Storage Conditions

    -20°C

    Tariff Code

    2941.50.0000

Applications

    Application

    Azithromycin impurity E is primarily used as a reference standard. Reference standards are well characterized compounds that can be used to help identify and/or quantify impurities in pharmaceutical compounds and antimicrobials.

Specifications

    Appearance

    Deep Yellow

    pH

    8-9

    Melting Point

    134.4°C-136°C

Technical Data

HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].

References

    References

    Gladue RP, Bright GM, Isaacson RE and Newborg MF (1989) In vitro and in vivouptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33(3):277-282 PMID 2543276

    Lovmar, M and Tenson T (2003) The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330 (5): 1005-014. PMID 12860123

    Wolf K and Malinverni R (1999) Effect of Azithromycin plus Rifampin versus that of Azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis. Antimicrob. Agents Chemother. 43(6): 1491-3. PMID 10348778

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