SKU: A122

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Description

Anguinomycin A is a natural polyketide product and analog of Leptomycin B, an inhibitor of protein nuclear export.  It is isolated from Streptomyces spp.  It has anti-cancer activity.  Anguinomycins B, C and D are also members of the Leptomycin family. 

 Anguinomycin A is soluble in ethanol and methanol but unstable in DMSO.

 We also offer:

  • Leptomycin A (L020)
  • Leptomycin B (L004)
  • Kazusamycin A (K018)
  • Kazusamycin B (K019)

    CAS Number

    111278-01-4

    Molecular Formula

    C31H44O6

    Molecular Weight

    512.7

    Storage Conditions

    -20°C

Applications

    Cancer Applications

    Anguinomycin A is cytotoxic to murine P388 leukemia cells in vitro at nanomolar concentration. It is also active in vivo against Lewis lung carcinoma in mice.

Specifications

    Form

    Solid

    Appearance

    Pale yellow film

    Source

    Streptomyces spp.

References

    References

    Bonazzi S et al (2010)  Anguinomycins and derivatives: Total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transport.  J. Am. Chem. Soc. 132 (4):1432-1442

    Hayakawa Y et al.(1995)  Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. J. Antibiot. 48:954

    Hayakawa Y, Adachi K and Komeshima N (1987)  New antitumor antibiotics, Anguinomycins A and B. J. Antibiot. 40:1349

     

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