SKU: A122

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Description
Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in vivo against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of leptomycin B, an inhibitor of nuclear export of proteins.

Anguinomycin A is soluble in ethanol and methanol (ethanol recommended). Unstable in DMSO.

    CAS Number

    111278-01-4

    Molecular Formula

    C31H44O6

    Molecular Weight

    512.7

    Storage Conditions

    -20°C

Specifications

    Appearance

    Pale yellow film

References

    References

    Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. Hayakawa Y ., et al. , J. Antibiot., 1995, 48, 954. 

    New antitumor antibiotics, anguinomycins A and B. Hayakawa Y., et al. , J. Antibiot., 1987, 40, 1349.

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