• Leptomycin A, EvoPure� packaged and labeled in glass vial.

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SKU: L020

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Description
Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.

Leptomycin A is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO. 

    CAS Number

    87081-36-5

    Molecular Formula

    C32H46O6

    Molecular Weight

    526.7

    Storage Conditions

    -20°C

Specifications

    Appearance

    Colourless Film

References

    References

    Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. Hamamoto T. et al. J Antibiot. 1983, 36, 639.

    Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. Hamamoto T. et al. J Antibiot. 1983, 36, 646.

    Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773.

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