• Kazusamycin A, EvoPure� packaged and labeled in glass vial.

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SKU: K018

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Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumor activity both in vitro and in vivo against P388 and L1210 cell lines, and also shows strong antibacterial and antifungal activity.

Kazusamycin A is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO. 

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    Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Wolff B., et al. , Chem. Biol., 1997, 4, 139.

    In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721). Roberts B. J., et al. , Cancer. Chemother. Pharmacol., 1986, 16, 95.

    Antitumor activity of a new antibiotic, kazusamycin. Komiyama K., et al. , J. Antibiot., 1985, 38, 224.

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