• Kazusamycin B, EvoPure� packaged and labeled in glass vial.

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SKU: K019

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Description
Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp.. It is an hydroxylated analogue of leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumor activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.

Kazusamycin B is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO. 

    CAS Number

    107140-30-7

    Molecular Formula

    C32H46O7

    Molecular Weight

    542.7

    Storage Conditions

    -20°C

Specifications

    Appearance

    Colourless Film

References

    References

    Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Wolff B. et al. Chem. Biol. 1997, 4, 139.

    The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. Takamiya K. et al. J. Antibiot. 1988, 41, 1854.

    PD 124,895 and PD 124,966, two new antitumor antibiotics. Hurley T.R. et al. J. Antibiot. 1986, 39, 1651.

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