Bleomycin sulfate, USP packaged and labeled.

191.58580.92
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B00510 mg
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  • Description

    Bleomycin sulfate is a water soluble anticancer chemotherapeutic agent commonly used to treat Hodgkin’s lymphoma. Bleomycin comprises a mixture of two components: bleomycin A2 and bleomycin B2. The approximate composition of A2:B2 is 2:1; however, the ratio can vary greatly depending on the lot tested.

    TOKU-E offers three forms of bleomycin: bleomycin sulfate (B005), bleomycin A2 sulfate, EvoPure® (B019), and bleomycin B2 sulfate, EvoPure® (B020). EvoPure® products are individual molecular fractions, most >99% pure.

    Mechanism of Action

    Bleomycin acts as an anticancer agent by causing single stranded breaks in DNA. The exact mechanism is not well defined however; it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which create single stranded breaks in deoxyribose sugar.

    • Cancer Applications

      Chemotherapeutic agent for the treatment of Hodgkin's lymphoma.

    • References

      Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.

      "Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.

    Form

    Powder

    Purity Level

    1.5 - 2.0 units/mg

    Tariff Code

    2941.90.5000

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number9041-93-4
    FormPowder
    AppearanceWhite or off-white crystalline powder
    Purity Level1.5 - 2.0 units/mg
    SourceStreptomyces verticillus
    pH4.5 - 6.0
    Storage Conditions2-8 °C
    Loss on Drying≤6.0%
    Heavy MetalsCopper: ≤0.1%
    IdentificationIR, Sulfate - Passes test