SKU: T014  / 
    CAS Number: 74610-55-2

    Tylosin Tartrate

    €58,22 - €297,01

    Tylosin tartrate is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics, the main component of the mixture (> 80%) is tylosin Atylosin B (desmycosin), tylosin C (macrocin), and tylosin D (relomycin) may also be present.  Tylosin has broad spectrum bacteriostatic activity against gram-positive bacteria and mycoplasma, but much less activity against most gram-negative bacteria and fungi.

    Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly bind to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibit mRNA-directed protein synthesis.

    Tylosin has been used to study protein synthesis, abscess prevention in cattle, and Mycoplasma infections.

    For more tylosin products click here.

    Mechanism of ActionMacrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to tylosin tartate is commonly attributed to mutations in 50S rRNA preventing tylosin tartate binding allowing the cell to synthesize proteins free of error.
    SpectrumTylosin tartate targets primarily gram positive bacteria and species of the Mycoplasma genus.
    Purity LevelComposition
    • Tylosin A: Not less than 80.0%
    • Sum of tylosin A, B, C, D: Not less than 95.0% 
    Microbiology ApplicationsTylosin tartate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Mycoplasma hyopneumoniae 0.015 µg/mL – 0.3 µg/mL
    • Streptococcus pneumoniae 0.125 µg/mL - 64 µg/mL
    • For a complete list of tylosin tartate MIC values, click here.
    Molecular FormulaC46H77NO17 · C4H606
    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

    MICHaemophilus parasuis| 2.5 - 40|| Mycoplasma hyosynoviae| ≤0.25 - 1|| Paenibacillus larvae| 0.016 - 0.031||