Sulfapyridine, USP is a first generation sulfonamide discovered in 1937 by L Whitby (May & Baker) and originally named M&B693. Sulfapyridine has anti-inflammatory properties and can be used in studies of immunodeficiency and inflammation. It can also be used in oxygen radical absorbance capacity (ORAC) where it scavenges peroxyl radicals. It is practically insoluble in water. Formulations with sodium have similar potency and improved water solubility.
We also offer:
- Sulfapyridine Sodium (S106)
| Mechanism of Action | Sulfapyridine inhibits folic acid synthesis by acting as a competitive inhibitor of dihydropteroate synthetase, an enzyme found in the folic acid synthesis pathway. |
| Spectrum | Sulfapyridine has broad-spectrum activity against most Gram-positive and many Gram-negative organisms. |
| Microbiology Applications | Sulfapyridine can be used to study inflammation. Many bacterial strains may be resistant, and resistance to one sulfonamide indicates resistance to all. |
| Molecular Formula | C11H11N3O2S |
| References |
Henry RJ (2012) The mode of action of sulfonamides. Bacteriol. Rev. (n.d.): 175-84 Paniker U and Levine (2001) Dapsone and Sulfapyridine. Dermatol. Clinics 19(1):79-86 |
