Antibacterials

Thimerosal

Thimerosal or Thiomersal is an organomercury compound with antibacterial and antifungal properties. Thimerosal was first patented by Morris Kharasch from the University of Maryland in 1927, and later given the trade name Merthiolate by Eli Lilly and...

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Rifampicin Sodium

Rifampicin Sodium (Rifampin) is a semisynthetic antimicrobial compound with immunosuppressive properties derived from Rifamycin SV and originally developed by the Lepetit group in 1965.  Rifampicin shows activity against Gram-positive bacteria,...

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7-Aminocephalosporanic Acid

7-Aminocephalosporanic Acid (7-ACA) is a key intermediate in the production of a wide variety of semisynthetic Cephalosporin antibiotics.  It is an inhibitor of bacterial (S. aureus) β-lactamase.  It is derived from mild acid...

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Oleandomycin

Oleandomycin is a 16-membered macrocyclic lactone, discovered in the 1950s, with broad-spectrum antibacterial activity. It has activity profile similar to erythromycin and penicillin.   It is synthesized from Streptomyces antibioticus. It was...

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Sulbactam

Sulbactam is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. In the presence of low concentrations of sulbactam, ampicillin and other β-lactams readily inhibit the growth of a variety of resistant bacteria that...

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Terrecyclic Acid

Terrecyclic acid is a tricyclic sesquiterpene antibiotic produced by Aspergillus terreus, first reported by researchers at the Universities of Osaka and Tokyo in 1982. Terrecyclic acid A had a wide antimicrobial spectrum of rather weak activities...

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Sulbactam Sodium

Sulbactam Sodium is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. In the presence of low concentrations of sulbactam, ampicillin and other β-lactams readily inhibit the growth of a variety of resistant bacteria...

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Lincomycin

Lincomycin is a lincosamide first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar...

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Toxoflavin

Toxoflavin (PKF 118-310) is an azapteridine antibiotic produced by some species of Pseudomonas, Streptomyces, and Burkholderia gladioli that has antibiotic and anticancer properties.  It is also a yellow pigment that acts as a pH indicator changing...

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Rifampicin

Rifampicin (syn: Rifampin) is a semisynthetic antimicrobial compound derived from rifamycin SV and originally developed by the Lepetit group in 1965.  Rifampicin shows activity against Gram-positive bacteria, particularly mycobacteria like...

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Cetrimide

Cetrimide is a bactericidal cationic surfactant used against Gram-positive bacteria.  It is commonly used in selective media to isolate Pseudomonas aeruginosa. Cetrimide is an active ingredient in Cetavlon, a detergent used in plant surface...

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Sisomicin Sulfate

Sisomicin sulfate is a soluble broad-spectrum aminoglycoside antibiotic, and a dihydro analog of gentamicin C1a sulfate, Evopure.  Sisomicin was first isolated in 1970 from Micromonopora inyoensis, a novel strain at the time, that was...

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