Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Nalidixic Acid Sodium, CulturePure® is a naphthyridone antibiotic similar in structure and mechanism to quinolones, the commercial preparation developed by Sanofi Aventis. The product is commonly used as a selective agent in many isolation...
Sulfamethizole is a broad-spectrum sulfathiazole antibacterial of the Sulfonamide class, used for the bacteria causing urinary tract infections. Acting as a synthetic analog of para-aminobenzoic acid (PABA), it competitively inhibits this...
Oseltamivir Phosphate is an inhibitor of influenza viral neuraminidase. It is also an antiviral used against influenza A and B. Oseltamivir was discovered at Gilead in 1997 using shikimic acid as a starting point for synthesis. The...
Posaconazole is a synthetic, broad-spectrum, second generation triazole with antifungal activity. It has potent in vitro and in vivo trypanocidal activity. It was discovered by Schering-Plough and it is a structural analog of itraconazole. It has...
Ceftazidime Hydrochloride is a non-toxic hydrochloride salt derivative of Ceftazidime, a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis. Patented in 1979 by Glaxo Group, it came into...
O-Methylviridicatin is a natural derivative of the alkaloid mycotoxin viridicatin produced by several species of Penicillium. The scaffold of quinolin-2(1H)-one is a useful structural motif found in many natural products. In particular,...
Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...
Tenofovir alafenamide is an antiretroviral developed by Gilead and the anti-HIV activity was reported in 1993. It is an investigational precursor to Tenovor, a nucleotide reverse transcriptase inhibitor. Tenofovir alafenamide is...
Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export. It is isolated from Streptomyces spp., and displays anti-cancer activity. Anguinomycins B, C and D are also members of the Leptomycin...
Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological...
Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains. It is a bioactive small molecule with antifungal and antibacterial activity. It is a nuclear export inhibitor,...
Miconazole Nitrate is the nitrate salt of Miconazole, an imidazole antimycotic compound patented in 1968 (Janssen Pharmaceutica). It targets the fungi that cause tinea (ringworm) and athlete’s foot. It inhibits ergosterol synthesis, and...