Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Secnidazole is a second-generation 5-nitroimidazole antibiotic and analog of metronidazole. It has in vitro activity against anaerobic bacteria and can be used in research for trichomoniasis, amoebiasis, giardiasis, and bacterial vaginosis. The compound...
Vaborbactam is a non-β-lactam β-lactamase inhibitor. It is synthetic biochemical based on a a cyclic boronic acid pharmacophore. It was discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. It can increase the potency of...
Ozenoxacin is a quinolone antibiotic with bacterididal activity against Staphylococcus aureus and Streptococcus pyogenes, the causal agents of impetigo. Ozenoxacin also has activity against some bacteria that are resistant to fluoroquinolones. The...
Dihydroartemisinin (syn: DHA) is a first-generation derivative of artemisinin, isolated from Artemisia annua, a traditional Chinese herb. It is the major metabolite of artemether, an antimalarial agent. DHA is used against Plasmodium falciparum, the...
Zidebactam is a non-β-lactam antibiotic that is categorized as a diabicyclooctane (DBO). It is a penicillin-binding protein 2 (PBP2) inhibitor with a high affinity for PBP2 in Gram-negative bacteria. When used in combination with cefepime, it can...
Trovafloxacin Mesylate is a broad-spectrum fluoroquinolone antibiotic. It was developed for immunology research (Pfizer). It can inhibit both Gram-positive and Gram-negative bacteria, and anaerobic organisms. The compound inhibits activity of DNA gyrase...
Ravuconazole is a triazole antifungal, a 1-butyl-1H-1,2,4- triazole. The compound has a broad-spectrum antifungal activity, and is active against molds and yeast. It has a spectrum similar to voriconazole. It inhibits cytochrome P450...
Efinaconazole is a triazole antifungal and 14α-demethylase inhibitor. The compound was synthesized as an azoleamine derivative (Kaken Phermaceutical Co). The fungal lanosterol 14α-demethylase is involved in the conversion of lanosterol to...
Geldanamycin ReadyMadeTM solution is provided as a sterile-filtered solution of Geldanamycin formulated in DMSO at a concentration of 1 mg/ml. It has been filter-sterilized using a 0.22 μm filter. Geldanamycin is a 1,4-benzoquinone ansamycin...
Amicoumacin B is a complex antibiotic and isocoumarin produced by Bacillus subtilis. This natural product, a fungal metabolite, is a quorum-sensing inhibitor with activity against Chromobacterium violaceum. It reduces the expression of C. violaceum...
Lecanoric acid is an orcinol depside found in a broad range of lichen and fungal species. Structurally, lecanoric acid is a dimer of orsellinic acid. Lecanoric acid is a broad antimicrobial agent, exhibiting more potent activity against bacteria than...
Midostaurin is an organic protein kinase inhibitor for tyrosine kinase, protein kinase C, and VEGF. It is an organic heterooctacyclic compound that is the N-benzoyl derivative of stauroporine, an alkaloid from Streptomyces staurosporeus. It has been...