• Paromomycin sulfate packaged and labeled.

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SKU: P002

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Description

Paromomycin sulfate is a freely soluble (50 mg/mL) aminoglycoside antibacterial and antiparasitic drug.

    CAS Number

    1263-89-4

    Molecular Formula

    C23H45N5O14 · H2SO4

    Molecular Weight

    713.71 g/mol

    Mechanism of Action

    Like many aminoglycosides, paromomycin targets the 16S rRNA of the 30S ribosomal subunit and prevents translocation and misreading of mRNA by stabilizing aminoacyl-tRNA in the acceptor (“A”) site.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.1010

    Spectrum

    Paromomycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria including Escherichia coli and Staphylococcus species.

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Impurity Profile

    LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).

    pH

    5.0-7.5

    Melting Point

    >200 °C

    Optical Rotation

    +50° to +55°

References

    References

    Davidson, R. N., and et al. "Paromomycin." Transactions of the Royal Society of Tropical Medicine and Hygiene 103.7 (2009): 653-60. www.ncbi.gov. Web. 6 Sept. 2012.

    Puglisi, Joseph D., and et al. "Paromomycin Binding Induces a Local Conformational Change in the A-site of 16 S RRNA." Journal of Molecular Biology 277.2 (1998): 335-45 www.ncbi.gov. Web. 6 Sept. 2012.

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