SKU: M018  / 
    CAS Number: 66803-19-8

    Micronomicin Sulfate


    Micronomicin Sulfate is the sulfate salt of Micronomicin, a natural aminoglycoside, broad-spectrum antibiotic discovered and developed by Kyowa Hakko Kogyo Co.  The structure was determined as 6’-N-methylgentamicin C1a, and it is similar to Gentamicin C in physicochemical and antimicrobial properties but unlike Gentamicin C,  it has remarkable activity against some gentamicin C1a-resistant strains.  It targets Gram-positive and Gram-negative bacteria by interfering with bacterial protein synthesis.  Micronomicin Sulfate is freely soluble in water.

    Mechanism of Action Aminoglycoside antibiotics target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
    Microbiology Applications Micronomicin Sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.
    Spectrum Micronomicin Sulfate has activity against Gram-positive and Gram-negative bacteria including S. aureus, S. epidermidis, E. coli, and P. aeruginosa. 
    Molecular Formula C20H41N5O7 •2.5H2SO4

    Davis BD (1987)  Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 51(3):341-350  PMID 3312985 

    Okachi R, Kawamoto I, Takasawa S, Yamamoto M, Sato S (1974) A new antibiotic XK-62-2 (Sagamicin).  I. Isolation, physicochemical and antibacterial properties. J. Antibiotics 27(10):793  PMID: 4457527