Apramycin sulfate is an aminoglycoside antibiotic which binds the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis. It is sparingly soluble in water (25 mg/mL).
|Mechanism of Action||Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.|
|Spectrum||Gram negative bacteria such as E. coli and Salmonella spp. demonstrate susceptibility to apramycin sulfate.|
|Microbiology Applications||Apramycin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:|
|Molecular Formula||C21H41N5O11 • H2SO4|
Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.
|MIC||Escherichia coli| 1 － >512|| Escherichia coli (ATCC 25922)| 4|| Haemophilus parasuis| 4 － 64|| Klebsiella pneumoniae| 2 － >256|| Pseudomonas aeruginosa| 4|||