• Gentamicin C1a sulfate, EvoPure packaged and labeled.

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SKU: G032

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Description

Gentamicin C1a sulfate is one of several components of the gentamicin C complex. Gentamicin C1a can comprise 10-35% gentamicin depending on the manufacturer or manufacturing process. The gentamicin C complex comprises approximately 80% gentamicin and exhibits the most potent antimicrobial activity. The higher antimicrobial activity of the group C gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments. Gentamicin C1a differs from gentamicin C1 by a methyl group in the 6’ position of the purpurosamine (2-amino-hexose) ring. Gentamicin C1a sulfate, EvoPure® is ≥95.0% gentamicin C1a.

For more gentamicin products, click here.

    CAS Number

    26098-04-4

    Molecular Formula

    C19H39N5O· xH2SO4 (lot specific)

    Molecular Weight

    449.54 g/mol (Free base)

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1010

    Spectrum

    Gentamicin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Gentamicin EvoPure® compounds can be used to study effects of individual gentamicin components on various bacterial strains.

      Representative MIC values include:

    • Bacillis subtilis ATCC 6633: 0.02 µg/mL
    • Escherichia coli ATCC 10536: 1.1µg/mL
    • Staphylococcus aureus ATCC 6538P 0.06 µg/mL

Specifications

    Form

    Powder

    Appearance

    White powder

    Solubility

    Soluble

    Source

    Micromonospora

    pH

    3.5-5.5

Technical Data

Spectral Data - Gentamicin C1a sulfate, EvoPure®


HNMR Spectra


      

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Solvent: D2O
Instrument: Varian 300
Frequency: 300 MHz

 

FTIR Spectra

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References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

    Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)

    Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.

    Weinstein, Marvin J. "Biological Activity of the Antibiotic Components of the Gentamicin Complex." Journal of Bacteriology 94.3 (1967): 789-90. Web. 15 Oct. 2013.

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