• Colistin sodium methanesulfonate packaged and labeled.

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SKU: C073

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Description

Colistin sodium methanesulfonate is considered an inactive prodrug of Colistin which means it is inactive until converted into Colistin by cellular enzymes. It is prepared by the reaction of colistin with formaldehyde, then sodium bisulfate.  It is  less potent and less toxic than colistin sulfate.  Colistin targets the bacterial cell membrane, leading to reduced permeability and cell death.  It is effective against Gram-negative bacteria.  It is freely soluble in aqueous solution.

TOKU-E offers three forms of Colistin:

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees.  Please contact us for details.

    CAS Number

    8068-28-8

    Molecular Formula

    C58H115N16Na5O28S5

    Molecular Weight

    1759.90

    Mechanism of Action

    Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability.

    Storage Conditions

    2-8 ┬░C

    Tariff Code

    2941.90.1050

    Spectrum

    Colistin primarily targets and disrupts the cell wall of gram negative bacteria.

Applications

    Microbiology Applications

    Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Shigella spp. 64 µg/mL -128 µg/mL
    • Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
    • For a complete list of colistin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    A white to slightly yellow fine powder

    Source

    Bacillus polymyxa

    pH

    6.5-8.5

    Optical Rotation

    -46° to -51°

    Assay

    ≥390 µg/mg

    Loss on Drying

    ≤5.0%

    Sulfated Ash

    16-21%

    Heavy Metals

    ≤20 ppm

    Endotoxin

    ≤390 µg/mg

References

    References

    Asano T, Kageyama K and Myakumachi (1999) Surface disinfestation of resting spores of Plasmodiophora brassicae used to infect hairy roots of Brassica spp. Phytopathol. 89(4):314-319 PMID 18944777

    Bergen, PJ, Li J, Rayner CR, and Nation RL (2006)  Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa. Antimicrob. Agents Chemother.  50(6): 1953-1958  PMID 16723551

    Falagas ME and Kasiakou SK and Saravolatz LD(2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin. Infect. Dis. 40(9):1333-1341 PMID 15825037

    Koen N, van Breda SV and Loots DT (2018) Elucidating the antimicrobial mechanisms of oclistin sulfate on Mycobacterium tuberculosis using metabolomics. Tuberculosis 1111:14-19 PMID 30029899

    Komura S, Kurahashi K (1979) Partial purification and properties of L-2,4-diaminobutyric acid activating enzyme from a polymyxin E producing organism. J. Biochem (Tokyo) 86:1013-1021

    Leifert C, Ritchie JY and Waites WM (1991) Contaminants of plant-tissue and cell cultures. World J. Microbiol. Biotechnol. 74):452-469 PMID 24425131

    Mueller MJ, Brodschelm W, Spannagl E and Zenk MH (1993) Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid. Proc. Natl. Acad. Sci. USA Vol. 90(16):7490-7494 PMID 11607420

    Wallace, SJ et al (2012)Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation J. Pharma Sci 101 (9):3347-3359 PMID 22623044

     

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