• Colistin sodium methanesulfonate packaged and labeled.

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SKU: C073

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Description

Colistin is a unique sparingly soluble cyclic polypeptide antibiotic known as a polymyxin. Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability. New Delhi metallo-β-lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin.

TOKU-E offers two forms of colistin: colistin sulfate (C083) and colistin sodium methanesulfonate (C073) (also known as colistimethate sodium). Both forms of colistin are freely soluble in aqueous solution.  Colistin sodium methanesulfonate (CMS) is considered an inactive prodrug which means it is inactive until converted into colistin by cellular enzymes.  Colistin sulfate (colistin) however, is the end product of CMS and does not require molecular conversion for antimicrobial properties. To see all available colistin products, click here.

    CAS Number

    8068-28-8

    Molecular Formula

    C58H115N16Na5O28S5

    Molecular Weight

    1759.90

    Mechanism of Action

    Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.1050

    Spectrum

    Colistin primarily targets and disrupts the cell wall of gram negative bacteria.

Applications

    Microbiology Applications

    Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Shigella spp. 64 µg/mL -128 µg/mL
    • Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
    • For a complete list of colistin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    A white to slightly yellow fine powder

    Source

    Bacillus polymyxa

    pH

    6.5-8.5

    Optical Rotation

    -46° to -51°

    Assay

    ≥390 µg/mg

    Loss on Drying

    ≤5.0%

    Sulfated Ash

    16-21%

    Heavy Metals

    ≤20 ppm

    Endotoxin

    ≤390 µg/mg

References

    References

    Falagas, M. E. "Colistin: The Revival of Polymyxins for the Management of Multidrug-resistant Gram-negative Bacterial Infections." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 40.9 (2005): 1333-341. www.ncbi.gov. Web. 10 Sept. 2012.

    Bergen, Philip J. et. al. "Colistin Methanesulfonate Is an Inactive Prodrug of Colistin against Pseudomonas Aeruginosa." Antimicrobial Agents and Chemotherapy 50.6 (2006): 1953-958. Ncbi.gov. Web. 5 Oct. 2012.

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