• Clindamycin hydrochloride packaged and labeled.

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SKU: C035

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Description

Clindamycin HCl is a lincosamide antibiotic.

TOKU-E offers two forms of clindamycin: clindamycin HCl (C035) and clindamycin phosphate (C036).  In aqueous solution, clindamycin HCl is slightly soluble (0.030 mg/mL) and clindamycin phosphate is freely soluble.

    CAS Number

    21462-39-5

    Molecular Formula

    C18H33ClN2O5S · HCl

    Molecular Weight

    461.44 g/mol

    Mechanism of Action

    Lincosamides inhibit bacterial protein synthesis by binding the 50S ribosomal subunit and interfering with tRNA activity during translation.

    Storage Conditions

    2-8 ┬░C. In an airtight container.

    Tariff Code

    2941.90.5000

    Spectrum

    Clindamycin is a broad spectrum antibiotic targeting primarily gram positive and gram negative bacteria such as Clostridium and Bacteroides species.

Applications

    Microbiology Applications

    Clindamycin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative anaerobes.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Clostridium difficile 0.25 µg/mL - 32 µg/mL
    • Bacteroides fragilis 0.25 µg/mL - 4 µg/mL
    • For a complete list of clindamycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    3.0-6.0%

    Potency (on a dry basis)

    ≥800 µg/mg (C18H33ClN2O5S)

    pH

    3.0-5.5

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

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