SKU: C233

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Clindamycin is a broad-spectrum antibiotic and antiparasitic agent.  It is a semi-synthetic derivative of Lincomycin, a natural lincosamide from Streptomyces lincolnensis.  It is obtained by chloride substitution of the exocyclic sugar hydroxy group for improved pharmacodynamics, and was first announced in 1966.  Clindamycin is freely soluble in water.

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    Mechanism of Action

    Clindamycin has a bacteriostatic effect, acts by reversible binding to the 50S rRNA of the large bacterial ribosome subunit, preventing ribosomal translocation and thus protein synthesis.

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    Clindamycin has broad-spectrum activity against Gram-positive and Gram-negative anaerobic bacteria, in addition to protozoa.


    Eukaryotic Cell Culture Applications

    HIV-infected MOLT3 cells were incubated with increasing concentrations of Clindamycin and did not result in increased cell death compared to uninfected control cells. (Wijsman et al, 2013).

    The effects of Clindamycin and its metabolites on mammalian cell lines (mouse leukemia L1210, human oral carcinoma KB, human acute myelogenous leukemia RPMI 6410, and human lymphocyte RPMI 1788) were evaluated.   Metabolites clindamycin sulfoxide and clindamycoase were nontoxic, wherease N-demethyl clindamycin showed cytotoxic effects in culture (Li LH et al (1977).



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    Dhawan VK and Thadepalli H. (1982)  Clindamycin: A review of fifteen years of experience. Clin. Infect. Dis. 4(6):1133-1153  PMID 6818656

    Li LH, Kuentzel K L, Shugars KD and Bhuyan BK (1977)  Cytotoxicity of several marketed antibiotics on mammalian cells in culture. J. Antibiot (Tokyo) 30(6):506-512  PMID 560364

    Lovmar, M and Tanel T (2003)  The Mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Molec. Microbiol.  330(5 ): 1005-014  PMID 12860123

    Magerlein BJ et al (1966)  Chemical modification of lincomycin. Antimicrob Agents Chemother. 6:727 PMID 5985307

    Wijsman JA, Dekaban GA and Rieder MJ (2013)  Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: Influence of HIV infection on clindamycin toxicity in vitro. J. Clin. Pharmacol. 45(3):346-351  PMID 15703369

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