• Ciprofloxacin hydrochloride packaged and labeled.

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SKU: C032

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Description

Ciprofloxacin HCl is a second generation fluoroquinolone antibiotic.

TOKU-E offers two forms of ciprofloxacin: ciprofloxacin (C031) and ciprofloxacin HCl (C032). Ciprofloxacin is sparingly soluble in aqueous solution (1.1 µg/mL). Ciprofloxacin HCl is freely soluble at 35 mg/mL.

    CAS Number

    86393-32-0

    Molecular Formula

    C17H18FN3O3 · HCl· H2O

    Molecular Weight

    385.82 g/mol

    Mechanism of Action

    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and cell division is inhibited.

    Storage Conditions

    2-8 ┬░C, protected from light.

    Tariff Code

    2933.59.3600

    Spectrum

    Ciprofloxacin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Ciprofloxacin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.

    • For a complete list of ciprofloxacin MIC values, click here.

    Plant Biology Applications

    The protoplast of the proposed progenitor of garlic (Allium longicuspis) was successfully cultured in medium containing ciproflaxacin. Ciprofloxacin did not appear to be toxic to protoplast viability but was successful in regulating microbial growth.

Specifications

    Form

    Powder

    Appearance

    White or off-white crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    4.7-6.7%

    pH

    3.0-4.5

    Assay

    98.0-102.0% (on dry basis)

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤0.002%

    Impurities

    Sulfate: ≤ 0.04%
    Fluoroquinolinic acid: ≤0.2%
    Ciprofloxacin ethylenediamine analog: ≤0.2%
    Any other impurity: ≤0.2% Total Impurities: ≤0.5%

References

    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

    Fellner M. Influence of the antibiotic ciprofloxacin on culture of Allium longicuspis callus-derived protoplasts. Annals of Botany 76: 219-223, 1995.

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