• Cefuroxime sodium packaged and labeled.

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SKU: C023

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Description

Cefuroxime sodium is a second-generation cephalosporin antibiotic and is freely soluble in aqueous solution (0.145 mg/mL).

    CAS Number

    56238-63-2

    Molecular Formula

    C16H15N4NaO8S

    Molecular Weight

    446.37 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many second generation cephalosporins, cefuroxime is relatively stable in the presence of β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefuroxime sodium is a broad spectrum antibiotic targeting a wide variety of gram negative and gram positive bacteria.

Applications

    Microbiology Applications

    Cefuroxime sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.25 µg/mL – 4 µg/mL
    • Neisseria gonorrhoeae 0.2 µg/mL – 1.6 µg/mL
    • For a complete list of cefuroxime MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to yellowish crystalline powder

    Source

    Synthetic

    Impurity Profile

    Individual Impurity: Not more than 1.0%
    Total Impurities: Not more than 3.0%

    Water Content (Karl Fischer)

    ≤3.5%

    pH

    6.0-8.5

    Optical Rotation

    +55° to +65º

    Assay

    (Dried Basis): Not less than 86.0%

Technical Data

Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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