SKU: C096  / 
    CAS Number: 82619-04-3

    Cefpodoxime Sodium

    $253.00

    Cefpodoxime Sodium is a broad-spectrum, third-generation cephalosporin β-lactam antibiotic that interferes with bacterial cell wall.  It is effective against a wide range of Gram-positive and Gram-negative bacteria.  Cefpodoxime Sodium is soluble in DMSO.

    We also offer:

    •  Cefpodoxime Proxetil (C015)
    •  Cefpodoxime Free Acid (C016)
    Mechanism of ActionLike β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.
    SpectrumCefpodoxime Sodium is a broad-spectrum antibiotic which targets a wide variety of Gram-positive and Gram-negative bacteria especially those which cause otitis media and pharyngitis.
    Microbiology ApplicationsCefpodoxime Sodium is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    • Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.032 µg/mL – 1 µg/mL
    • For a complete list of cefpodoxime MIC values, click here.

    Cefpodoxime from TOKU-E was used as a reference compound when characterizing the extended-spectrum AmpC (ESAC) B-lactamase enzymes (Lahiri et al, 2014).

    In vitro kinetic modeling can be used to study the pharmacokinetic-pharmacodynamic modelling of the antibacterial activity of cefpodoxime.  This approach has more detailed information than the MIC about he time course of efficacy (Liu et al, 2005).
    Molecular FormulaC15H16N5NaO6S2
    References

    Georgopapadakou NH (1992)  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37(3):559-565

    Lahiri SD, Giacobbe RA, Johnstone MR and Alm RA (2014)  Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C β-lactamase enzyme. J. Antimicrob. Chemother. 69(11):2942–2946  PMID

    Liu P, Rand KH, Obermann B and Derendorf H (2005)  Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models. Int. J. Antimicrob. Agents 25(2):120-129  PMID 15664481

    Wise R,  Andrews JM, Ashby JP and Thornber D (1990)  The in-vitro activity of cefpodoxime: a comparison with other oral cephalosporins.  J. Antimicrob. Chemother.  25(4):541–550  PMID 2351624

    Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3."

    MICBacteroides bivius| 0.25 - >64| 1492| Bacteroides disiens| 0.25 - >64| 1492| Bacteroides distasonis| 0.25 - >64| 1492| Bacteroides fragilis| 0.25 - >64| 1492| Bacteroides fragilis| 8 - 128| 401| Bacteroides fragilis (NCTC 9343)| 32 - ?| 401| Bacteroides ovatus| 0.25 - >64| 1492| Bacteroides thetaiotaomicron| 0.25 - >64| 1492| Bacteroides vulgatus| 0.25 - >64| 1492| Brucella abortus| 0.25 - ?| 1492| Brucella melitensis| 0.25 - ?| 1492| Brucella suis| 0.25 - ?| 1492| Burkholderia cepacia| 16 - >128| 600| Citrobacter amalonaticus| 16 - ?| 1481| Citrobacter amalonaticus (4026 + β-lactamase positive)| 8 - ?| 1481| Citrobacter braakii| >16 - ?| 1481| Citrobacter farmeri| 1 - >16| 1481| Citrobacter freundii| 0.5 - >128| 600| Citrobacter freundii| 4 - >16| 1481| Citrobacter freundii (3757 + β-lactamase positive)| 128 - ?| 1481| Citrobacter spp.| 16 - >16| 1481| Citrobacter werkmanii| >16 - ?| 1481| Clostridium difficile| 64 - >64| 1492| Clostridium histolyticum| 0.25 - 16| 1492| Clostridium sordellii| 0.25 - 16| 1492| Clostridium sporogenes| 0.25 - 16| 1492| Enterobacter aerogenes| 0.25 - >64| 1492| Enterobacter aerogenes| 1 - >16| 1481| Enterobacter aerogenes (3701 + β-lactamase positive)| 32 - ?| 1481| Enterobacter amnigenus| >16 - ?| 1481| Enterobacter asburiae| >16 - ?| 1481| Enterobacter cloacae| 0.03 - >64| 1492| Enterobacter cloacae| 0.125 - >128| 600| Enterobacter cloacae| 8 - >16| 1481| Enterobacter cloacae (22491)| 2 - ?| 386| Enterobacter cloacae (3146 + β-lactamase positive)| 64 - ?| 1481| Enterobacter cloacae (53 + β-lactamase positive)| 32 - ?| 1481| Enterobacter hormaechei| 8 - >16| 1481| Enterobacter intermedius| >16 - ?| 1481| Enterobacter sakazakii| 0.13 - 1| 1492| Enterobacter taylorae| >16 - ?| 1481| Enterobacteriaceae| 0.06 - 128| 401| Enterococci| 1 - 128| 401| Enterococcus faecalis| 1 - >128| 600| Enterococcus faecalis| >64 - ?| 1492| Enterococcus faecalis (ATCC 29212)| >32 - ?| 401| Enterococcus faecium| >64 - ?| 1492| Enterococcus faecium| 128 - >128| 600| Enterococcus liquefaciens| >64 - ?| 1492| Escherichia coli| 0.125 - 8| 600| Escherichia coli| 0.12 - 512| 946| Escherichia coli| ? - ?| 946| Escherichia coli (ampicillin-resistant + ceftazidime-resistant)| 16 - 32| 1492| Escherichia coli (ampicillin-resistant + ceftazidime-susceptible)| 0.13 - 0.25| 1492| Escherichia coli (ampicillin-susceptible)| 0.13 - 0.5| 1492| Escherichia coli (ATCC 25922)| 0.25 - ?| 401| Escherichia coli (ATCC 25922)| 0.5 - ?| 290| Escherichia coli (ATCC 35218)| 0.5 - ?| 290| Escherichia coli (NCTC 10418)| 0.25 - ?| 401| Escherichia coli (OC4075)| 1 - ?| 290| Escherichia coli (OC4087)| >128 - ?| 290| Escherichia coli (OC4136)| >128 - ?| 290| Escherichia coli (OC4138)| 32 - ?| 290| Escherichia coli (OC4227)| 8 - ?| 290| Escherichia coli (OC4229)| 16 - ?| 290| Escherichia coli (OC4249)| 64 - ?| 290| Escherichia coli (OC6028)| 64 - ?| 290| Escherichia coli (OC6042)| 128 - ?| 290| Escherichia coli (OC6043)| >128 - ?| 290| Escherichia coli (OC6044)| >128 - ?| 290| Haemolytic streptococci| 0.015 - 0.12| 401| Haemophilus influenzae| ≤0.03 - 1| 500| Haemophilus influenzae| 0.032 - 0.5| 600| Haemophilus influenzae (ampicillin-resistant)| 0.03 - 1| 1492| Haemophilus influenzae (ampicillin-susceptible)| 0.03 - 0.5| 1492| Haemophilus influenzae (ATCC 49247)| 0.5 - ?| 401| Haemophilus influenzae (ESBL)| <0.03 - 0.12| 84| Haemophilus influenzae (ESBL)| ≤0.03 - 0.5| 114| Haemophilus influenzae (ESBL)| <0.03 - 0.5| 84| Haemophilus influenzae (ESBL)| ≤0.03 - 0.5| 195| Haemophilus influenzae (NCTC 11931)| 0.12 - ?| 401| Haemophilus influenzae (non-ESBL)| ≤0.03 - 0.5| 195| Haemophilus influenzae (non-ESBL)| ≤0.03 - 0.5| 114| Haemophilus parainfluenzae| 0.06 - 0.13| 1492| Haemophilus spp.| 0.06 - 0.5| 401| Hafnia alvei| 16 - ?| 1481| Helicobacter pylori| 0.5 - 4| 1492| Klebsiella oxytoca (ceftazidime-resistant)| 2 - ?| 1492| Klebsiella oxytoca (ceftazidime-susceptible)| 0.06 - 2| 1492| Klebsiella pneumonia| 0.063 - 32| 600| Klebsiella pneumonia (ATCC 13883)| ≤0.12 - ?| 290| Klebsiella pneumonia (ATCC 700603)| 8 - ?| 290| Klebsiella pneumonia (OC4074)| 128 - ?| 290| Klebsiella pneumonia (OC4076)| 32 - ?| 290| Klebsiella pneumonia (OC4105)| 32 - ?| 290| Klebsiella pneumonia (OC4110)| >128 - ?| 290| Klebsiella pneumonia (OC4239)| 64 - ?| 290| Klebsiella pneumonia (OC4244)| >128 - ?| 290| Klebsiella pneumonia (OC4250)| >128 - ?| 290| Klebsiella pneumonia (OC5064)| >128 - ?| 290| Klebsiella pneumoniae (ceftazidime-resistant)| 8 - 64| 1492| Klebsiella pneumoniae (ceftazidime-susceptible)| 0.03 - 4| 1492| Klebsiella rhinoscleromatis| >16 - ?| 1481| Listeria innocua| 2 - >64| 1492| Listeria ivanovii| 2 - >64| 1492| Listeria monocytogenes| 2 - >64| 1492| Listeria seeligeri| 2 - >64| 1492| Listeria welshimeri| 2 - >64| 1492| Moraxella catarrhalis| 0.06 - 0.5| 1492| Moraxella catarrhalis| 0.06 - 2| 84| Moraxella catarrhalis| 0.06 - 2| 114| Moraxella catarrhalis| 0.06 - 4| 195| Moraxella catarrhalis| 0.063 - 2| 600| Moraxella catarrhalis| ? - ?| 403| Moraxella catarrhalis| ≤0.03 - >4| 500| Morganella morganii| 0.13 - 64| 1492| Morganella morganii| 0.125 - 64| 600| Morganella morganii| 8 - >16| 1481| Neisseria gonorrhoeae (penicillin-resistant)| 0.004 - 0.06| 1492| Neisseria gonorrhoeae (penicillin-susceptible)| 0.004 - 0.06| 1492| Neisseria spp.| 0.002 - 0.06| 401| Pneumococci| 0.03 - 4| 401| Proteus mirabilis| 0.06 - 0.13| 1492| Proteus mirabilis| 0.032 - 0.125| 600| Proteus mirabilis| <=0.25 - 4| 1481| Proteus mirabilis (3750 + β-lactamase positive)| 8 - ?| 1481| Proteus penneri| 16 - ?| 1481| Proteus penneri (1767 + β-lactamase positive)| 32 - ?| 1481| Proteus vulgaris| 0.06 - 0.5| 1492| Proteus vulgaris| 0.032 - 16| 600| Proteus vulgaris| <=0.25 - >16| 1481| Proteus vulgaris (1405 + β-lactamase positive)| 128 - ?| 1481| Proteus vulgaris (1699 + β-lactamase positive)| 128 - ?| 1481| Proteus vulgaris (1765 + β-lactamase positive)| >128 - ?| 1481| Proteus vulgaris (1781 + β-lactamase positive)| 1 - ?| 1481| Providencia rettgeri| ≤0.004 - 8| 600| Providencia rettgeri| ≤0.004 - 8| 600| Providencia rettgeri| 0.008 - 2| 1492| Providencia rettgeri| <=0.25 - 0.5| 1481| Providencia stuartii| 0.06 - 0.5| 1492| Providencia stuartii| <=0.25 - >16| 1481| Pseudomonas aeruginosa| >128 - ?| 600| Pseudomonas aeruginosa (ATCC 27853)| >128 - ?| 401| Pseudomonas aeruginosa (carbenicillin-resistant)| >64 - ?| 1492| Pseudomonas aeruginosa (carbenicillin-susceptible)| >64 - ?| 1492| Pseudomonas aeruginosa (NCTC 10662)| 128 - ?| 401| Pseudomonas cepacia| 4 - >64| 1492| Pseudomonas fluorescens| 8 - >64| 1492| Pseudomonas putida| 8 - >64| 1492| Pseudomonas spp.| 0.25 - 128| 401| Pseudomonas stutzeri| 8 - >64| 1492| Salmonella Agona| 0.13 - 0.5| 1492| Salmonella Brandenburg| 0.13 - 0.5| 1492| Salmonella Enteritidis| 0.13 - 0.5| 1492| Salmonella typhimurium| 0.13 - 0.5| 1492| Serratia fonticola| >16 - ?| 1481| Serratia liquefaciens| 0.25 - >64| 1492| Serratia marcescens| 0.5 - >128| 600| Serratia marcescens| 0.25 - >64| 1492| Serratia marcescens| 2 - >16| 1481| Serratia marcescens (167 + β-lactamase positive)| >128 - ?| 1481| Serratia marcescens (91 + β-lactamase positive)| >128 - ?| 1481| Serratia plymuthica| 8 - ?| 1481| Serratia rubidaea (3134 + β-lactamase positive)| 2 - ?| 1481| Serratia rubidaea (3139 + β-lactamase positive)| 4 - ?| 1481| Shigella boydii| 0.25 - 0.5| 1492| Shigella flexneri| 0.25 - 0.5| 1492| Shigella sonnei| 0.25 - 0.5| 1492| Staphylococci| 1 - 128| 401| Staphylococcus aureus (ATCC 25923)| 4 - ?| 401| Staphylococcus aureus (ATCC 29213)| 2 - ?| 401| Staphylococcus aureus (ATCC 6571)| 1 - ?| 401| Staphylococcus aureus (methicillin-resistant)| 16 - >64| 1492| Staphylococcus aureus (methicillin-resistant)| 1 - >128| 600| Staphylococcus aureus (oxacillin-susceptible)| ? - ?| 403| Staphylococcus epidermidis (methicillin-resistant)| 4 - >64| 1492| Staphylococcus epidermidis (methicillin-resistant)| 4 - >128| 600| Staphylococcus epidermidis (methicillin-susceptible)| 0.25 - 16| 600| Staphylococcus epidermidis (methicillin-susceptible)| 0.5 - 4| 1492| Staphylococcus haemolyticus (methicillin-resistant)| >64 - ?| 1492| Staphylococcus hominis| 0.5 - 2| 1492| Staphylococcus intermedius| ? - ?| 946| Staphylococcus pseudintermedius| 0.25 - 8| 1397| Staphylococcus simulans| 0.5 - 2| 1492| Staphylococcus warneri| 0.5 - 1| 1492| Stenotrophomonas maltophilia| >128 - ?| 600| Streptococci| ? - ?| 403| Streptococci (hemolytic + group A)| 0.008 - 0.5| 1492| Streptococci (hemolytic + group B)| 0.03 - 0.25| 1492| Streptococci (hemolytic + group C)| 0.015 - 0.03| 1492| Streptococci (hemolytic + group G)| 0.015 - 0.06| 1492| Streptococcus agalactiae| 0.032 - 0.063| 600| Streptococcus milleri (group)| 0.015 - 0.25| 1492| Streptococcus mitior| 0.015 - 0.13| 1492| Streptococcus pneumonia| ? - ?| 403| Streptococcus pneumonia (ATCC 49619)| 0.12 - ?| 401| Streptococcus pneumonia (ATCC 5303 parent)| 0.015 - ?| 287| Streptococcus pneumonia (ATCC 6303 parent)| 0.03 - ?| 287| Streptococcus pneumonia (pbp2x and pbp2b or pbp1a and pbp2x genes abnormal + penicillin)| 0.125 - 8| 121| Streptococcus pneumonia (pbp2x gene abnormal + penicillin-intermidiate)| 0.063 - 2| 121| Streptococcus pneumonia (pbpla, pbp2x, and pbp2b genes abnormal + penicillin-resistant)| 1 - 32| 121| Streptococcus pneumonia (penicillin-intermediate)| 0.05 - 2| 469| Streptococcus pneumonia (penicillin-intermediate)| ≤0.03 - >4| 114| Streptococcus pneumonia (penicillin-intermediate)| <0.03 - >4| 84| Streptococcus pneumonia (penicillin-intermediate)| ≤0.03 - >4| 195| Streptococcus pneumonia (penicillin-intermediate)| ? - ?| 418| Streptococcus pneumonia (penicillin-intermediate)| 0.12 - 4| 287| Streptococcus pneumonia (penicillin-resistant)| 0.063 - 16| 600| Streptococcus pneumonia (penicillin-resistant)| 1.861 - 8| 469| Streptococcus pneumonia (penicillin-resistant)| ≤0.03 - >4| 114| Streptococcus pneumonia (penicillin-resistant)| <0.03 - >4| 84| Streptococcus pneumonia (penicillin-resistant)| ≤0.03 - >4| 195| Streptococcus pneumonia (penicillin-susceptible)| ? - ?| 418| Streptococcus pneumonia (penicillin-susceptible)| ≤0.03 - 4| 114| Streptococcus pneumonia (penicillin-susceptible)| <0.03 - 4| 84| Streptococcus pneumonia (penicillin-susceptible)| ≤0.03 - 4| 195| Streptococcus pneumonia (penicillin-susceptible)| 0.016 - 0.5| 121| Streptococcus pneumonia (penicillin-susceptible)| 0.023 - 0.064| 469| Streptococcus pneumonia (penicillin-susceptible)| 0.008 - 1| 600| Streptococcus pneumonia (penicillin-susceptible)| 0.008 - 2| 287| Streptococcus pneumoniae (penicillin-susceptible)| 0.015 - 0.13| 1492| Streptococcus pyogenes| ≤0.004 - 2| 600| Xanthomonas maltophilia| >64 - ?| 1492| Yersinia enterocolitica| 0.5 - 2| 1492|