• Cefixime trihydrate packaged and labeled.

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SKU: C051

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Description

Cefixime trihydrate is a broad spectrum third generation cephalosporin targeting a wide range of gram positive and gram negative organisms. Cefixime trihydrate is especially useful against pathogens responsible for causing ear, nose, and throat infections such as Haemophilus influenzae and Moraxella catarrhalis.

    CAS Number

    125110-14-7

    Molecular Formula

    C16H15N5O7S2 • 3 H2O

    Molecular Weight

    507.50

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefixime however, is resistant to many β-lactamases encoded by β-lactam resistant strains.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

Applications

    Microbiology Applications

    Cefixime trihydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.008 µg/mL – 2 µg/mL
    • Moraxella catarrhalis 0.06 µg/mL – 0.5 µg/mL
    • For a complete list of cefixime MIC values, click here.

    Media Supplements

    Cefixime can be used as a selective agent in several types of isolation media:

    Sorbitol Macconkey Agar - Cefixime-Tellurite Supplement

    mTSB - VCC Selective Supplement

    CR-SMAC - Cefixime Supplement

Specifications

    Form

    Powder

    Appearance

    Light yellow crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    9.0-12.0%

    pH

    2.6-4.1

    Optical Rotation

    -75° to -88°

    Assay

    (On Dried Basis): 950-1030 µg/mg

    Impurities

    Chromatographic Purity:
    Individual Impurity: ≤1.0%
    Total Impurities: ≤2.0%

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