• Cefditoren pivoxil packaged and labeled.

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SKU: C050

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Description

Cefditoren pivoxil is a third generation cephalosporin antibiotic.

TOKU-E offers three forms of cefditoren: cefditoren (C100)cefditoren sodium (C094), and cefditoren pivoxil (C050). Cefditoren sodium is soluble in aqueous solution, and cefditoren pivoxil is soluble in fat.

    CAS Number

    117467-28-4

    Molecular Formula

    C25H28N6O7S3

    Molecular Weight

    620.72 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefditoren is a broad spectrum antibiotic commonly used against bacteria responsible for community acquired pneumonia and pharyngitis

Applications

    Microbiology Applications

    Cefditoren pivoxil can be used to study antibiotic effects against group A Streptococcus and other microbes responsible for phayrngitis.

Specifications

    Form

    Powder

    Appearance

    Light yellow or off-white crystalline powder

    Water Content (Karl Fisher)

    ≤1.5%

    Optical Rotation

    -45° - -52°

    Assay

    944-1005 µg/mg (on dried basis)

    Residue On Ignition

    ≤0.2%

    Heavy Metals

    ≤10 ppm

    Impurities

    Single Impurity: ≤0.1%
    Total Impurities: ≤5.0%

References

    References

    Poveda, J. L., et al. "Cefditoren Pivoxil: A New Oral Cephalosporin for Skin, Soft Tissue and Respiratory Tract Infections." Medline 19.3 (n.d.): 231-46.www.ncbi.gov. Web. 27 Aug. 2012.

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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