Cefteram pivoxil is a third generation cephalosporin antibiotic. Cefteram pivoxil contains a pivoxil group which increases lipophilicity. Cefteram pivoxil is freely soluble in ethanol, acetonitrile, methanol, and chloroform.
| Mechanism of Action | Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. |
| Spectrum | Like many third generation cephalosporins, cefteram is mostly active against gram negative bacteria especially those which cause meningitis and gonorrhea. |
| Molecular Formula | C22H27N9O7S2 |
| Impurities | Single Impurity: ≤1.5% Total Impurities: ≤2.0% |
| References | "Serious hypocarnitinemia and hypoglycaemia in Children treated with antibacterials with a Pivoxil group." Pmda.go.jp. N.p., n.d. Web. 8 Apr. 2014. Fuchs, Tarr. "Case Study: Cefditoren Pivoxil: An Oral Prodrug of Cefditoren." Prodrugs V (2007): 1185-194. Link.springer.com. Web. 8 Apr. 2014. |
