• Cefditoren sodium packaged and labeled.

click on thumbnail to zoom
SKU: C094

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Cefditoren sodium is a third generation cephalosporin antibiotic.

TOKU-E offers three forms of cefditoren: cefditoren (C100), cefditoren sodium (C094), and cefditoren pivoxil (C050). Cefditoren sodium is soluble in aqueous solution, and cefditoren pivoxil is soluble in fat.

    CAS Number

    104146-53-4

    Molecular Formula

    C19H17N6NaO5S3

    Molecular Weight

    528.56

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefditoren is a broad spectrum antibiotic commonly used against bacteria responsible for community acquired pneumonia and pharyngitis.

Applications

    Microbiology Applications

    Cefditoren sodium can be used to study antibiotic effects against group A Streptococcus and other microbes responsible for phayrngitis.

Specifications

    Form

    Powder

    Appearance

    White or white-like crystalline powder

    Assay

    (On Dried Basis): ≥99.0%

References

    References

    Poveda, J. L., et al. "Cefditoren Pivoxil: A New Oral Cephalosporin for Skin, Soft Tissue and Respiratory Tract Infections." Medline 19.3 (n.d.): 231-46.www.ncbi.gov. Web. 27 Aug. 2012.

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

Other Items In This Category