SKU: P017  / 
    CAS Number: 61477-96-1

    Piperacillin

    €81,38 - €115,47

    Piperacillin is a semi-synthetic, extended spectrum fungistatic β-lactam fourth-generation ureidopenicillin.  It was developed by Toyama Chemical Co, Tokyo, Japan and is derived from Ampicillin.  Piperacillin is commonly used in combination with the β -lactamase inhibitor Tazobactam.  It can be used to study multidrug resistance. 

    Piperacillin is sparingly soluble in aqueous solution.

    • Piperacillin Sodium (P010)
    Mechanism of Action β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
    Spectrum Piperacillin is broad-spectrum,  targeting a wide range of susceptible Gram-positive and Gram-negative bacteria.  It targets both aerobic and anaerobic bacteria.  It can be used against Enterococcus species, Pseudomonas aeruginosa, and E. coli.
    Impurity Profile Related Substances:
    Impurity A: ≤ 1.0%
    Impurity B: ≤ 0.2%
    Impurity C: ≤ 0.4%
    Impurity D: ≤ 2.0%
    Ampicillin: ≤ 0.2%
    Microbiology Applications Piperacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  It is commonly used in a mixture with the beta-lactamase inhibitor Tazobactam which enhances is effectiveness. Representative MIC values include:
    • Neisseria spp. 0.015 µg/mL – 32 µg/mL
    • Bacteroides fragilis 0.25 µg/mL - 32 µg/mL

    For a representative list of Piperacillin MIC values, click here.

    Plant Biology Applications In vitro antibacterial activity of Piperacillin against Agrobacterium tumefaciens strains LBA4404 and EHA101 was examined and found to be effective in eliminating the bacteria involved in Agrobacterium-mediated plant genetic transformation (Ogawa and Mii, 2004).
    Molecular Formula C23H27N5O7S
    Solubility Sparingly soluble in aqueous solution.
    References

    Ogawa Y and Mii M (2004)  Screening for highly active beta-lactam antibiotics against Agrobacterium tumefaciens. Arch. Microbiol. 181:331-336

    Pitout JD, Sanders CC, and Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 103:51

    MIC Bacteroides bivius| ? - ?| 1385| Bacteroides caccae| 32 - >128| 1475| Bacteroides distasonis| 4 - >256| 1468| Bacteroides fragilis| ? - ?| 381| Bacteroides fragilis| ? - ?| 1385| Bacteroides fragilis| 0.06 - >128| 340| Bacteroides fragilis| <=0.06 - 75| 1468| Bacteroides fragilis| 0.5 - >128| 1475| Bacteroides fragilis| 2.5 - 128| 401| Bacteroides fragilis| 256 - ?| 652| Bacteroides fragilis (1995)| 0.5 - >256| 297| Bacteroides fragilis (1996)| 1 - >256| 297| Bacteroides fragilis (ATCC 23745)| 2 - ?| 386| Bacteroides fragilis (cephalosporin-resistant)| 64 - ?| 652| Bacteroides fragilis (Europe)| ? - ?| 284| Bacteroides fragilis (group)| 0.12 - >=256| 1480| Bacteroides fragilis (group)| 0.2 - >256| 1468| Bacteroides fragilis (group)| 1 - >128| 1475| Bacteroides fragilis (NCTC 9343)| 2 - ?| 401| Bacteroides fragilis (North America)| ? - ?| 284| Bacteroides fragilis gr.| 0.25 - 32| 497| Bacteroides melaninogenicus| ? - ?| 1385| Bacteroides ovatus| ? - ?| 1385| Bacteroides thetaiotaomicron| ? - ?| 1385| Bacteroides thetaiotaomicron| 4 - >256| 1468| Bacteroides thetaiotaomicron| 8 - >128| 1475| Bacteroides uniformis| 2 - >256| 1468| Bacteroides uniformis| 64 - >128| 1475| Bacteroides vulgatus| ? - ?| 1385| Bacteroides vulgatus| 4 - 256| 1468| Bacteroides vulgatus| 1 - >128| 1475| Bifidobacterium spp.| ≤0.004 - 2| 340| Borrelia burgdorferi S.L.| <0.06 - 0.125| 1129| Brucella| 0.2 - 32| 1388| Burkholderia cepacia| 2 - >128| 140| Burkholderia cepacia| 1 - >512| 97| Burkholderia cepacia (Europe)| ? - ?| 284| Burkholderia cepacia (North America)| ? - ?| 284| Candida albicans (GC 3066)| >128 - ?| 209| Citrobacter diversus (Hyperproducing amp(C))| 128 - ?| 652| Citrobacter diversus (Inducible amp(C))| 4 - ?| 652| Citrobacter freundii| ≤0.5 - 128| 412| Citrobacter freundii| ? - ?| 323| Citrobacter freundii (Basal amp(C))| 1 - ?| 652| Citrobacter freundii (Europe)| ? - ?| 284| Citrobacter freundii (Hyperproducing amp(C))| 64 - ?| 652| Citrobacter freundii (Inducible amp(C))| 1 - ?| 652| Citrobacter freundii (North America)| ? - ?| 284| Citrobacter koseri (Europe)| ? - ?| 284| Citrobacter koseri (North America)| ? - ?| 284| Clostridium bifermentans| ? - ?| 1385| Clostridium butyricum| <=0.03 - 2| 1475| Clostridium clostridioforme| <=0.03 - 2| 1475| Clostridium difficile| ? - ?| 381| Clostridium difficile| ? - ?| 1385| Clostridium difficile (Europe)| ? - ?| 284| Clostridium difficile (North America)| ? - ?| 284| Clostridium perfringens| ≤0.004 - 4| 340| Clostridium perfringens| <=0.03 - ?| 1475| Clostridium perfringens| ? - ?| 1385| Clostridium perfringens (Europe)| ? - ?| 284| Clostridium perfringens (North America)| ? - ?| 284| Clostridium ramosum| <=0.03 - 2| 1475| Clostridium ramosum| ? - ?| 1385| Clostridium septicum| <=0.03 - 2| 1475| Clostridium species (NOS)| ? - ?| 1385| Clostridium sporogenes| <=0.03 - 2| 1475| Clostridium sporogenes| ? - ?| 1385| Clostridium spp.| ≤0.004 - >128| 340| Corynebacterium jeikeium| 8 - >64| 29| Edwardsiella hoshinae| 0.13 - ?| 1409| Edwardsiella ictaluri| 0.13 - 4| 1409| Edwardsiella tarda| 0.13 - 4| 1409| Enterobacter aerogenes (Europe)| ? - ?| 284| Enterobacter aerogenes (North America)| ? - ?| 284| Enterobacter cloacae (032349)| 2 - ?| 386| Enterobacter cloacae (22491)| 4 - ?| 386| Enterobacter cloacae (Basal amp(C))| 2 - ?| 652| Enterobacter cloacae (Europe)| ? - ?| 284| Enterobacter cloacae (GC 3783)| 32 - ?| 209| Enterobacter cloacae (Hyperproducing amp(C))| 256 - ?| 652| Enterobacter cloacae (Inducible amp(C))| 2 - ?| 652| Enterobacter cloacae (North America)| ? - ?| 284| Enterobacter spp.| ? - ?| 323| Enterobacteriaceae| 0.25 - 128| 401| Enterococcus faecalis (ATCC 29212)| 2 - ?| 401| Enterococcus faecalis (Europe)| ? - ?| 284| Enterococcus faecalis (GC 2242)| 2 - ?| 209| Enterococcus faecalis (GC 4555)| 1 - ?| 209| Enterococcus faecalis (GC 6189)| 2 - ?| 209| Enterococcus faecalis (GC 842)| 2 - ?| 209| Enterococcus faecalis (North America)| ? - ?| 284| Enterococcus faecium| 8 - >128| 89| Enterococcus faecium (Europe)| ? - ?| 284| Enterococcus faecium (GC 2243)| 128 - ?| 209| Enterococcus faecium (GC 4556)| 2 - ?| 209| Enterococcus faecium (GC 4558)| >128 - ?| 209| Enterococcus faecium (North America)| ? - ?| 284| Enterococcus spp.| 4 - >128| 89| Escherichia coli| ? - ?| 323| Escherichia coli| >128 - ?| 6| Escherichia coli (ATCC 25922)| 1.9 - ?| 665| Escherichia coli (Basal amp(C))| 1 - ?| 652| Escherichia coli (C921-61)| 2 - ?| 955| Escherichia coli (DH10B + pDG-1)| 32 - ?| 651| Escherichia coli (DH10B + pNOR-2001)| 4 - ?| 657| Escherichia coli (DH10B)| 1 - ?| 657| Escherichia coli (DH10B)| 1 - ?| 651| Escherichia coli (DH10B)| 1 - ?| 1451| Escherichia coli (ESBL)| ≤0.5 - >64| 412| Escherichia coli (Europe)| ? - ?| 284| Escherichia coli (GC 2203)| 1 - ?| 209| Escherichia coli (GC 3226)| 0.5 - ?| 209| Escherichia coli (GC 4559)| 1 - ?| 209| Escherichia coli (HB101)| 0.5 - ?| 1449| Escherichia coli (Hyperproducing amp(C))| 32 - ?| 652| Escherichia coli (imp + GC 4560)| <0.12 - ?| 209| Escherichia coli (K-10)| 2 - ?| 955| Escherichia coli (K-10)| 2 - ?| 955| Escherichia coli (K-12)| 2 - ?| 955| Escherichia coli (North America)| ? - ?| 284| Escherichia coli (XL1)| 1 - ?| 1449| Eubacterium spp.| 0.008 - 16| 340| Fusobacterium mortiferum| 0.12 - >128| 1475| Fusobacterium necrophorum| 0.12 - >128| 1475| Fusobacterium nucleatum| ? - ?| 381| Fusobacterium nucleatum| 0.12 - >128| 1475| Fusobacterium spp.| ≤0.004 - 128| 340| Fusobacterium spp.| 0.12 - >128| 1475| Fusobacterium varium| 0.12 - >128| 1475| Haemophilus influenzae (Europe)| ? - ?| 284| Haemophilus influenzae (North America)| ? - ?| 284| Haemophilus spp.| 0.004 - 128| 401| Klebsiella pneumonia| ≤0.12 - >256| 412| Klebsiella pneumonia| 128 - ?| 6| Klebsiella pneumonia (ESBL)| ? - ?| 1298| Klebsiella pneumonia (Europe)| ? - ?| 284| Klebsiella pneumonia (GC 4534)| 4 - ?| 209| Klebsiella pneumonia (North America)| ? - ?| 284| Klebsiella pneumonia (SHV-1)| 8 - ?| 652| Klebsiella pneumonia (β-lactamase negative)| 1 - ?| 652| Klebsiella spp.| ? - ?| 323| Lactobacillus spp.| 0.12 - 4| 340| Morganella morganii| ? - ?| 323| Morganella morganii (Europe)| ? - ?| 284| Morganella morganii (GC 4531)| 128 - ?| 209| Morganella morganii (Hyperproducing amp(C))| 32 - ?| 652| Morganella morganii (Inducible amp(C))| 0.5 - ?| 652| Morganella morganii (North America)| ? - ?| 284| Neisseria meningitidis (Europe)| ? - ?| 284| Neisseria meningitidis (North America)| ? - ?| 284| Neisseria spp.| 0.015 - 32| 401| Ochrobactrum anthropi (SLO74)| >=128 - ?| 1449| Pasteurella multocida| <8 - ?| 1092| Pemphigus mirabilis (Europe)| ? - ?| 284| Pemphigus mirabilis (North America)| ? - ?| 284| Pemphigus vulgaris (Europe)| ? - ?| 284| Pemphigus vulgaris (North America)| ? - ?| 284| Peptococcus asaccharolyticus| ? - ?| 1385| Peptostreptococcus anaerobius| <=0.03 - 64| 1475| Peptostreptococcus anaerobius| ? - ?| 1385| Peptostreptococcus anaerobius (Europe)| ? - ?| 284| Peptostreptococcus magnus| <=0.03 - 64| 1475| Peptostreptococcus micros| <=0.03 - 64| 1475| Peptostreptococcus spp.| ≤0.004 - 32| 340| Peptostreptococcus spp.| <=0.03 - 64| 1475| Peptostreptococcus spp.| ? - ?| 381| Prevotella bivia (Europe)| ? - ?| 284| Prevotella bivia (North America)| ? - ?| 284| Prevotella buccae| 0.25 - 128| 1475| Prevotella intermedia| 0.25 - 128| 1475| Prevotella melaninogenica (Europe)| ? - ?| 284| Prevotella melaninogenica (North America)| ? - ?| 284| Prevotella melaninogenicus| 0.25 - 128| 1475| Prevotella oralis| 0.25 - 128| 1475| Prevotella spp.| ? - ?| 381| Prevotella spp.| 0.25 - 128| 1475| Propionibacterium| ? - ?| 381| Proteus vulgaris| ? - ?| 323| Proteus vulgaris (Hyperproducing amp(C))| 32 - ?| 652| Proteus vulgaris (Inducible amp(C))| 1 - ?| 652| Providencia rettgeri| ? - ?| 323| Providencia rettgeri (Europe)| ? - ?| 284| Providencia rettgeri (North America)| ? - ?| 284| Providencia stuartii| ? - ?| 323| Providencia stuartii (Europe)| ? - ?| 284| Providencia stuartii (North America)| ? - ?| 284| Pseudomonas aeruginosa| 2 - >128| 248| Pseudomonas aeruginosa| ? - ?| 323| Pseudomonas aeruginosa| 4 - ?| 665| Pseudomonas aeruginosa| 6.6 - ?| 142| Pseudomonas aeruginosa (14)| 4 - ?| 788| Pseudomonas aeruginosa (1405 + amp(C)-DEF opr(D)+)| 8 - ?| 48| Pseudomonas aeruginosa (555)| >256 - ?| 664| Pseudomonas aeruginosa (695)| 512 - ?| 664| Pseudomonas aeruginosa (ATCC 15692)| 2 - ?| 786| Pseudomonas aeruginosa (ATCC 27853)| 1.9 - ?| 665| Pseudomonas aeruginosa (carbapenem-resistant)| 32 - ?| 652| Pseudomonas aeruginosa (cbr(A) mutant)| 4 - ?| 788| Pseudomonas aeruginosa (cbr(B) mutant)| 4 - ?| 788| Pseudomonas aeruginosa (COL-1)| 64 - ?| 657| Pseudomonas aeruginosa (DB5218)| 2 - ?| 786| Pseudomonas aeruginosa (DR3062)| 16 - ?| 786| Pseudomonas aeruginosa (ED-1)| 8 - ?| 651| Pseudomonas aeruginosa (Europe)| ? - ?| 284| Pseudomonas aeruginosa (GC 2214)| 2 - ?| 209| Pseudomonas aeruginosa (GC 4532)| 4 - ?| 209| Pseudomonas aeruginosa (GW-1)| 128 - ?| 664| Pseudomonas aeruginosa (JES-1)| 128 - ?| 664| Pseudomonas aeruginosa (mucoid)| 0.5 - >512| 97| Pseudomonas aeruginosa (non-mucoid)| 1 - >512| 97| Pseudomonas aeruginosa (North America)| ? - ?| 284| Pseudomonas aeruginosa (OHD)| <2 - ?| 913| Pseudomonas aeruginosa (OXA-10)| 64 - ?| 652| Pseudomonas aeruginosa (OXA-11)| 64 - ?| 652| Pseudomonas aeruginosa (PA01)| 2 - ?| 786| Pseudomonas aeruginosa (PAO)| <2 - ?| 913| Pseudomonas aeruginosa (PER-1)| 8 - ?| 652| Pseudomonas aeruginosa (post-treatment)| 12.5 - ?| 661| Pseudomonas aeruginosa (pretreatment)| 12.5 - ?| 661| Pseudomonas aeruginosa (PT121)| 2 - ?| 786| Pseudomonas aeruginosa (PU21 + pGIR-1)| 16 - ?| 651| Pseudomonas aeruginosa (PU21)| 2 - ?| 651| Pseudomonas aeruginosa (RNL-1)| 32 - ?| 664| Pseudomonas aeruginosa (RP-1)| 256 - ?| 664| Pseudomonas aeruginosa (Stel)| 32 - ?| 664| Pseudomonas cepacia| 8 - >128| 248| Pseudomonas spp.| 0.5 - 512| 401| Ralstonia pickettii (PIC-1)| 2 - ?| 1451| Salmonella typhimurium (LT2)| 4 - ?| 955| Serratia marcescens| 0.12 - >=256| 475| Serratia marcescens (Europe)| ? - ?| 284| Serratia marcescens (GC 4077)| 2 - ?| 209| Serratia marcescens (Hyperproducing amp(C))| 32 - ?| 652| Serratia marcescens (IMP-1)| 32 - ?| 652| Serratia marcescens (Inducible amp(C))| 2 - ?| 652| Serratia marcescens (North America)| ? - ?| 284| Serratia spp.| ? - ?| 323| Staphylococci| 0.25 - 128| 401| Staphylococci (coagulase-negative + methicillin-resistant)| 8 - >128| 89| Staphylococci (coagulase-negative + methicillin-susceptible)| ≤0.12 - 128| 89| Staphylococcus (GC 4537 + coagulase-negative)| 8 - ?| 209| Staphylococcus (GC 4538 + coagulase-negative)| 32 - ?| 209| Staphylococcus (GC 4539 + coagulase-negative)| >128 - ?| 209| Staphylococcus (GC 4548 + coagulase-negative + methicillin-resistant)| 32 - ?| 209| Staphylococcus (GC 4549 + coagulase-negative + methicillin-resistant)| 16 - ?| 209| Staphylococcus (GC 6257 + coagulase-negative + methicillin-resistant)| 2 - ?| 209| Staphylococcus aureus (ATCC 35556)| 0.5 - ?| 955| Staphylococcus aureus (Europe)| ? - ?| 284| Staphylococcus aureus (FDA 209P)| 4 - ?| 349| Staphylococcus aureus (GC 1131)| >128 - ?| 209| Staphylococcus aureus (GC 2216)| 4 - ?| 209| Staphylococcus aureus (GC 4536)| 0.5 - ?| 209| Staphylococcus aureus (GC 4541)| >128 - ?| 209| Staphylococcus aureus (GC 4543)| 0.5 - ?| 209| Staphylococcus aureus (GC 4543)| 1 - ?| 209| Staphylococcus aureus (JSB20013)| 0.5 - ?| 748| Staphylococcus aureus (methicillin-resistant)| 128 - >128| 89| Staphylococcus aureus (MU3)| 128 - ?| 349| Staphylococcus aureus (MU50)| 128 - ?| 955| Staphylococcus aureus (N315)| 32 - ?| 955| Staphylococcus aureus (North America)| ? - ?| 284| Staphylococcus aureus (RN4220/tet(A)/pYH4)| 0.25 - ?| 748| Staphylococcus epidermidis (Europe)| ? - ?| 284| Staphylococcus epidermidis (North America)| ? - ?| 284| Staphylococcus haemolyticus (GC 4547)| >128 - ?| 209| Stenotrophomonas maltophilia| 16 - 256| 249| Streptococcus agalactiae| 0.25 - 0.5| 89| Streptococcus pneumonia (Europe)| ? - ?| 284| Streptococcus pneumonia (GC 1894)| 2 - ?| 209| Streptococcus pneumonia (GC 6242)| <0.12 - ?| 209| Streptococcus pneumonia (North America)| ? - ?| 284| Streptococcus pneumonia (penicillin-intermediate)| 0.25 - 8| 89| Streptococcus pneumonia (penicillin-susceptible)| ≤0.2 - 0.5| 89| Streptococcus pyogenes| ≤0.2 - ?| 89| Veillonella parvula| <=0.03 - 128| 1475| Veillonella spp.| 0.06 - 64| 340| Veillonella spp.| <=0.03 - 128| 1475|