Oligomycin A is a dominant analog of the Oligomycin class of macrocyclic lactones isolated from selected strains of Streptomyces sp. The class includes the analogs/isomers A through G. Different isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Oligomycin A is an inhibitor of mitochondrial F1F0 ATP synthase. The Oligomycin complex was first reported in 1954, from a strain of Streptomyces diastatochromogenes from soil which was highly active against fungi. Oligomycins exhibit apoptotic cytotoxicity and mitochondrial toxicity.
Oligomycin A is soluble in ethanol, methanol, DMSO and DMF. It has poor water solubility.
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