Mitoxantrone Hydrochloride is an anti-cancer agent used chemotherapeutically for leukemias and solid tumors. It has immunosuppressive activity and inhibits proliferation of lymphocytes and induces apoptosis of antigen-presenting T-cells. The compound is sparingly soluble in water.
|Mechanism of Action||Mitoxantrone inhibits division of T-cells, B-cells, and macrophages by preventing DNA repair and synthesis, however, this also occurs in healthy cells. It is a cytostatic anthracenedione that induces double-strand breaks in DNA.|
|Cancer Applications||Mitoxantrone is commonly used in cancer research to study breast cancer, leukemia, and non-Hodgkin’s lymphoma.|
|Molecular Formula||C22H28N4O6 · 2 HCl|
Fox EJ (2004) Mechanism of action of mitoxantrone. Neurol. 63(12 Suppl 6):S15-S18 PMID 15623664